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C3196

Sigma-Aldrich

S(−)-Cathinone hydrochloride

Synonym(s):

α-Aminopropiophenone hydrochloride, S(−)-2-Amino-1-phenyl-1-propanone hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C9H11NO · HCl
CAS Number:
71031-15-7
Molecular Weight:
185.65
MDL number:
MFCD00673264
UNSPSC Code:
12352200
PubChem Substance ID:
24892592
NACRES:
NA.77

form

powder

Quality Level

200

drug control

USDEA Schedule I; Home Office Schedule 1; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIA (Portugal)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

H2O: soluble
ethanol: soluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

storage temp.

2-8°C

SMILES string

Cl.C[C@H](N)C(=O)c1ccccc1

InChI

1S/C9H11NO.ClH/c1-7(10)9(11)8-5-3-2-4-6-8;/h2-7H,10H2,1H3;1H/t7-;/m0./s1

InChI key

HPZCAKYHISJOIK-FJXQXJEOSA-N

Related Categories

General description

Cathinone is a monoamine alkaloid of Khat shrub. It is a β-keto derivative of amphetamine. Cathinone is structurally similar to dopamine and amphetamine. A synthetic cathinone is categorized as a new psychoactive substance.

Biochem/physiol Actions

Cathinone is the major central nervous system stimulant. Like amphetamine, it is a potent releaser of norepinephrine and dopamine from their intracellular stores. Cathinone derivates are known to have prolonged effects on nervous and blood vascular systems. The mode of action of its derivative is by inhibiting the reuptake of neurotransmitters and stimulating cathinone-sensitive receptors.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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E A Pehek et al.
Neuropharmacology, 29(12), 1171-1176 (1990-12-01)
The effects of (-)cathinone, the primary psychoactive alkaloid of the Khat plant, were compared to those of (+)amphetamine in the anterior caudate-putamen and the nucleus accumbens. In vivo microdialysis was used to measure extracellular levels of dopamine and metabolites in
A E Fleckenstein et al.
European journal of pharmacology, 382(1), 45-49 (1999-11-11)
High-dose administrations of amphetamine, methamphetamine, cathinone, methcathinone or methylenedioxymethamphetamine rapidly decrease dopamine and serotonin transporter function in vivo, as assessed in striatal synaptosomes obtained from drug-treated rats. In contrast, high-dose injections of fenfluramine, cocaine or methylphenidate had little or no
D J Calcagnetti et al.
Progress in neuro-psychopharmacology & biological psychiatry, 17(4), 637-649 (1993-07-01)
1. The objective of Exp. 1 was to determine whether intracerebroventricular (ICV) injection of cathinone CATH (8.0-32 micrograms) would produce a dose-dependent conditioned place preference (CPP) and/or activation in rats. Results indicate that rats conditioned with 16 or 32 micrograms
Issues of false negative results in toxicology: difficult in detecting certain drugs and issues with detection of synthetic cathinone (bath salts), synthetic cannabinoids (spice), and other new psychoactive substances
Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction, 257-270 (2019)
Toxicology and the clinical laboratory
Contemporary Practice in Clinical Chemistry, 913-947 (2020)
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