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50246

Sigma-Aldrich

Poloxamer 407, micronized

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lμtrol micro 127

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About This Item

CAS Number:
9003-11-6
MDL number:
MFCD00082049
UNSPSC Code:
12161900
NACRES:
NA.25

mol wt

~9840-14600 g/mol

Quality Level

100

composition

oxyethylene content, 71.5-74.9%

impurities

≤0.25% ethylene glycol and diethylene glycol
≤0.4% total ash
≤0.75% water
≤1 ppm ethylene oxide
≤2 ppm arsenic
≤20 ppm heavy metals
50-125 ppm butylhydroxytoluene

ign. residue

≤0.30%

color

APHA: ≤120

particle size distribution

, coeff var ≤10% (residue, No. 140 USS)
, coeff var ≤50% (residue, No. 270 USS)

pH

5.0-7.5(1:10)
5.0-7.5(1:40)

suitability

complies for Infrared spectrum

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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Application

The Poloxamer 407 grades are poloxamers from the extensive line of Pluronic® block copolymers. They are widely used as a thickening agent and gel binder.

Analysis Note

residual solvents (GLC-HS)
1,4-dioxane ≤5 ppm, ethylene glycol ≤620 ppm ( verified on random samples only)

Other Notes

average molecular weight/mass 9840-14600 g/mol; average molecular mass 10000-14600 g/mol

Legal Information

Pluronic is a registered trademark of BASF

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Céline Durand-Gasselin et al.
Langmuir : the ACS journal of surfaces and colloids, 27(20), 12329-12335 (2011-09-29)
Aggregation of thermosensitive polymer-coated gold nanoparticles was performed in aqueous solution in the presence of a triblock copolymer poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic P123, PEO(20)-PPO(68)-PEO(20)). The gold nanoparticles, AuNPs, which are covered by thermosensitive statistical copolymers poly(EO(x)-st-PO(y)), aggregate when the
Wei Xu et al.
Drug delivery, 19(4), 208-219 (2012-05-31)
The aim of this study was to construct novel targeting polymeric micelles. Folate-Poly (ethylenimine)-Pluronic copolymers were synthesized. A paclitaxel (PTX)-loaded mixed micelles consisting of Folate-Poly (ethylenimine)-Pluronic and Pluronic L121 copolymers have been developed. The mixed micelles showed nano-sized spherical morphology.
Irshad A Wani et al.
Colloids and surfaces. B, Biointerfaces, 101, 243-250 (2012-09-27)
Silver nanoparticles have been synthesized in the inverse microemulsions formed using three different surfactants viz., cetyl-trimethyl ammonium bromide (CTAB), Tergitol and Triton X-100. We have done a systematic study of the effect of the surfactants on the particle size and
Wendell J Lu et al.
Lipids, 47(6), 571-580 (2012-02-03)
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins produced in the intestine that play a central role in glucose metabolism and insulin secretion. Circulating concentrations of GLP-1 and GIP are low and can be difficult to assay in
Wanhua Feng et al.
Colloids and surfaces. B, Biointerfaces, 105, 43-50 (2013-01-29)
The interaction between bacteria and surfaces is central to many environmental, industrial and medical applications. Surfactants are commonly used in these applications and can potentially influence the bacterium/surface interaction. The effect of surfactants upon bacterial cell surface thermodynamic properties was
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