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C85751

Sigma-Aldrich

p-Cresol

99%

Synonym(s):

4-Methylphenol

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About This Item

Linear Formula:
CH3C6H4OH
CAS Number:
106-44-5
Molecular Weight:
108.14
Beilstein:
1305151
EC Number:
203-398-6
MDL number:
MFCD00002376
UNSPSC Code:
12352002
PubChem Substance ID:
329775178
NACRES:
NA.21

vapor density

3.72 (vs air)

Quality Level

200

vapor pressure

1 mmHg ( 20 °C)

Assay

99%

form

(Liquid, Solid, or Crystalline Solid)

autoignition temp.

1038 °F

expl. lim.

1 %
1.1 %, 150 °F

bp

202 °C (lit.)

mp

32-34 °C (lit.)

density

1.034 g/mL at 25 °C (lit.)

SMILES string

Cc1ccc(O)cc1

InChI

1S/C7H8O/c1-6-2-4-7(8)5-3-6/h2-5,8H,1H3

InChI key

IWDCLRJOBJJRNH-UHFFFAOYSA-N

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General description

p-Cresol, also known as 4-methylphenol, is an organic compound frequently utilized as an intermediate to synthesis various chemicals. It belongs to the phenol family and is an isomer of o-cresol and m-cresol.

Application


  • Detoxification of sewage sludge by natural attenuation and implications for its use as a fertilizer on agricultural soils.: This article discusses the role of p-Cresol in the detoxification processes of sewage sludge, considering its implications for safe agricultural use, addressing environmental and health concerns (Mazzeo DEC et al., 2016).

  • Characterization of livestock odors using steel plates, solid-phase microextraction, and multidimensional gas chromatography-mass spectrometry-olfactometry.: This research characterizes the complex odors of livestock environments, highlighting the role of p-Cresol in odor profiles, which could help improve management practices and mitigate odor emissions (Bulliner EA et al., 2006).

Pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

Signal Word

Danger

Hazard Statements

H301 + H311,H314,H412

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

Flash Point(F)

186.8 °F - closed cup

Flash Point(C)

86 °C - closed cup

Certificates of Analysis (COA)

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K Akasaka et al.
Journal of chromatography, 617(2), 205-211 (1993-08-11)
Cholesterol ester (ChE) and triacylglycerol (TG) hydroperoxides in human plasma were determined by high-performance liquid chromatography with postcolumn detection with diphenyl-1-pyrenylphosphine. Human plasma was extracted once with n-hexane. 2,6-Di-tert.-butyl-4-methylphenol and N-stearylcinnamide were added to human plasma before extraction as an
Fangxin Hu et al.
Analytica chimica acta, 724, 40-46 (2012-04-10)
In this paper, the reduced graphene oxide and multiwall carbon nanotubes hybrid materials (RGO-MWNTs) were prepared and a strategy for detecting environmental contaminations was proposed on the basis of RGO-MWNTs modified electrode. The hybrid materials were characterized by the scanning
Yu-Sen Peng et al.
Toxicology, 302(1), 11-17 (2012-07-21)
High serum levels of p-cresol have been associated with cardiovascular diseases. This study investigated the effects of p-cresol on gap junctions in neonatal cultured cardiomyocytes. p-Cresol reduced the spontaneous contraction rates of cardiomyocytes, and caused irregular cardiomyocyte beating. Junctional connexin
Michaël Carboni et al.
Inorganic chemistry, 51(19), 10447-10460 (2012-09-20)
The heterodinuclear complexes [Fe(III)Mn(II)(L-Bn)(μ-OAc)(2)](ClO(4))(2) (1) and [Fe(II)Mn(II)(L-Bn)(μ-OAc)(2)](ClO(4)) (2) with the unsymmetrical dinucleating ligand HL-Bn {[2-bis[(2-pyridylmethyl)aminomethyl]]-6-[benzyl-2-(pyridylmethyl)aminomethyl]-4-methylphenol} were synthesized and characterized as biologically relevant models of the new Fe/Mn class of nonheme enzymes. Crystallographic studies have been completed on compound 1 and
Laetitia Koppe et al.
Journal of the American Society of Nephrology : JASN, 24(1), 88-99 (2013-01-01)
The mechanisms underlying the insulin resistance that frequently accompanies CKD are poorly understood, but the retention of renally excreted compounds may play a role. One such compound is p-cresyl sulfate (PCS), a protein-bound uremic toxin that originates from tyrosine metabolism
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