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Key Documents

PHR1503

Supelco

Cilostazol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Cilostazol, 6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-2(1H)-quinolinone, OPC 13013, OPC 21, Pletaal

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About This Item

Empirical Formula (Hill Notation):
C20H27N5O2
CAS Number:
Molecular Weight:
369.46
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

Pricing and availability is not currently available.

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to USP 1134153

API family

cilostazol

CofA

current certificate can be downloaded

packaging

package of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

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1 of 4

This Item
1134153PHR1676PHR1653
format

neat

format

neat

format

neat

format

neat

Quality Level

300

Quality Level

-

Quality Level

300

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

storage temp.

2-30°C

storage temp.

-

storage temp.

2-30°C

storage temp.

2-30°C

packaging

package of 1 g

packaging

-

packaging

pkg of 100 mg

packaging

pkg of 100 mg

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Cilostazol is a dihydro-quinolinone derivative, that is predominantly used as an anti-platelet and vasodilatory agent. It acts by inhibition of cyclic adenosine monophosphate (cAMP) phosphodiesterase, which results in elevation of cAMP levels in platelets and blood vessels, thus inhibiting platelets aggregation.[1]

Application

Cilostazol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.[2][3]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA3090 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Cilostazol (Pletal ?): a dual inhibitor of cyclic nucleotide phosphodiesterase type 3 and adenosine uptake
    Liu YS, et al.
    Cardiovascular Drug Reviews, 19(4), 369-386 (2001)
    HPLC determination of cilostazol in tablets, and its validation
    Lestari AD, et al.
    Journal of Liquid Chromatography and Related Technologies, 27(16), 2603-2612 (2004)
    Validated stability-indicating methods for determination of cilostazol in the presence of its degradation products according to the ICH guidelines
    Fayed AS, et al.
    Journal of Pharmaceutical and Biomedical Analysis, 45(3), 407-416 (2007)

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