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O0146000

Olsalazine sodium

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

4,4′-Dihydroxyazobenzene-3,3′-dicarboxylic acid disodium salt, 5,5′-Azobis(salicylic acid, sodium salt), Mordant Yellow 5

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About This Item

Empirical Formula (Hill Notation):
C14H8N2Na2O6
CAS Number:
6054-98-4
Molecular Weight:
346.20
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

olsalazine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,15,17H,(H,19,20)(H,21,22);;/q;2*+1/p-2/b16-8-;;

InChI key

QQWFSVYVHLECFP-XBPUGJBTSA-L

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Olsalazine sodium EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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When less is not more but at least equivalent.
Stephen Holland
Inflammatory bowel diseases, 10(6), 890-891 (2005-01-01)
Danial E Baker et al.
Reviews in gastroenterological disorders, 4(2), 86-91 (2004-06-10)
5-aminosalicylic acid agents are effective in the treatment of ulcerative colitis. Balsalazide, mesalamine, and olsalazine are alternative formulations to sulfasalazine for the delivery of 5-aminosalicylic acid. The newer compounds might be better tolerated than sulfasalazine in some patients, as long
T-M-H Nguyen et al.
International journal of clinical pharmacology and therapeutics, 48(4), 275-281 (2010-04-01)
Aminosalicylates are widely used with azathioprine in the treatment of IBD. The association results in an increase in 6-TGN levels in adults with IBD with a difference in the occurrence of myelotoxic effects. Scarce data are available in pediatric population.
Lynn W Maines et al.
Inflammopharmacology, 18(2), 73-85 (2010-02-13)
Activation of sphingosine kinase (SK) is a key response to many inflammatory processes. The present studies test the hypothesis that an orally available SK inhibitor, ABC294640, would be effective in rodent models of Crohn's disease. Trinitrobenzene sulfonic acid (TNBS) was
B Nigović et al.
Die Pharmazie, 57(7), 468-470 (2002-08-10)
The electrochemical behavior of 2-hydroxy-5-[(4-sulfophenyl)azo]benzoic acid, 2-hydroxy-5-[(3-sulfophenyl)azo]benzoic acid and 2-hydroxy-5-[(2-sulfophenyl)-azo]benzoic acid was investigated by cyclic voltammetry using a glassy carbon electrode. The influence of the pH and position of the substituents on the reaction pathway has been studied. The results
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