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Key Documents

I2752

Sigma-Aldrich

L-Isoleucine

≥98% (HPLC)

Synonym(s):

(2S,3S)-2-Amino-3-methylpentanoic acid

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About This Item

Linear Formula:
C2H5CH(CH3)CH(NH2)CO2H
CAS Number:
Molecular Weight:
131.17
Beilstein:
1721792
EC Number:
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

product name

L-Isoleucine, reagent grade, ≥98% (HPLC)

grade

reagent grade

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white

mp

288 °C (dec.) (lit.)

solubility

1 M NH4OH: 50 mg/mL

application(s)

detection

SMILES string

CC[C@H](C)[C@H](N)C(O)=O

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Application

L-Isoleucine has been used in capillary feeder (CAFE) assay in a study to determine the consumption of amino acids by Drosophila melanogaster.[1] It has also been used as one of the components of an amino acid mixture, which is used as a supplement for synthetic complete (SC) media.[2]

Biochem/physiol Actions

L-Isoleucine is an isomer of L-leucine[3] and is an essential amino acid.[4] It is synthesized from threonine[5] and is a branched-chain hydrophobic amino acid.[6][7]

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Conversion of ammonia or urea into essential amino acids,L-leucine,L-valine, andL-isoleucine using artificial cells containing an immobilized multienzyme system and dextran-NAD+
    Applied Biochemistry and Biotechnology, 26 (1990)
    Mated Drosophila melanogaster females consume more amino acids during the dark phase
    Shun U
    PLoS ONE (2017)
    Inhibitory effect of aroma on the bitterness of branched-chain amino acid solutions.
    Mukai J
    Chemical & Pharmaceutical Bulletin, 55(11) (2007)
    Amino Acid Biosynthesis Is Regulated by Feedback Inhibition
    Biochemistry (5th Edition) null
    Michel Fleck, Aram M. Petrosyan
    Salts of Amino Acids: Crystallization, Structure and Properties (2014)

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