213136

Hydroxylamine-O-sulfonic acid

97%

• Linear Formula: H₂NOSO₃H
• CAS Number: 2950-43-8
• Molecular Weight: 113.09
• EC Number: 220-971-6
• MDL number: MFCD00011604
• UNSPSC Code: 12352300
• PubChem Substance ID: 57647921
• NACRES: NA.21

Properties

• Quality Level: 200
• Assay: 97%
• mp: 210 °C (dec.) (lit.)
• storage temp.: 2-8°C
• SMILES string: NOS(O)(=O)=O
• InChI: 1S/H3NO4S/c1-5-6(2,3)4/h1H2,(H,2,3,4)
• InChI key: DQPBABKTKYNPMH-UHFFFAOYSA-N

Description

General description

Hydroxylamine-O-sulfonic acid is a versatile synthetic reagent. It is widely employed as a nucleophile and as an electrophile in various organic syntheses. It can be synthesized by reacting hydroxylamine sulfate with 30% fuming H₂SO₄.

Application

Hydroxylamine-O-sulfonic acid (HOSA) may be employed in the preparation of the following:

• monosubstituted and 1,1-disubstituted hydrazines
• symmetrically substituted pyrroles
• aniline
• C-substituted amino derivatives
• lactams

Hydroxylamine-O-sulfonic acid may be used in the following processes:
As a nitrogen transfer reagent for the conversion of aldehydes to nitriles in aqueous medium.
Synthesis of N-aminopiperidine (NAPP) by reacting with piperidine.

Safety Information

• Pictograms: GHS05,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H302,H314,H410
• Precautionary Statements: P260 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves