AG733
Tamm-Horsfall Glycoprotein
Synonym(s):
THP, UMOD, Uromodulin
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About This Item
UNSPSC Code:
12352200
eCl@ss:
32160405
NACRES:
NA.41
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biological source
human
Quality Level
Assay
>95%
form
solid
manufacturer/tradename
Chemicon®
technique(s)
activity assay: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Gene Information
human ... UMOD(7369)
Related Categories
General description
Research area: Immuno and CKS
Tamm-Horsfall glycoprotein (THGP) also known as uromodulin is abundantly present in mammalian urine. It is highly expressed in the thick ascending limb of the Henle′s loop in the kidney. This protein consists of three epidermal growth factor (EGF) domains and a zona pellucida-like domain. THGP is a member of the glycosylphosphatidylinositol (GPI) protein family and is attached to the cell membrane by a C-terminal GPI- anchor. The THGP gene is located on the human chromosome at 16p12.3.
Tamm-Horsfall glycoprotein (THGP) also known as uromodulin is abundantly present in mammalian urine. It is highly expressed in the thick ascending limb of the Henle′s loop in the kidney. This protein consists of three epidermal growth factor (EGF) domains and a zona pellucida-like domain. THGP is a member of the glycosylphosphatidylinositol (GPI) protein family and is attached to the cell membrane by a C-terminal GPI- anchor. The THGP gene is located on the human chromosome at 16p12.3.
Application
Tamm-Horsfall Glycoprotein has been used in luciferase activity assay of immortalized proximal tubular cells and human primary proximal tubular epithelial cells. It has also been used as a standard for calibration of uromodulin in urine samples.
Biochem/physiol Actions
Tamm-Horsfall glycoprotein (THGP) may play a role in antibacterial host defense, inflammatory kidney disease, and the urogenital tract. It exhibits protective effects against kidney stone formation by reducing the calcium oxalate precipitation. Mutations in the THGP gene lead to familial juvenile hyperuricemic nephropathy (FJHN), glomerulocystic kidney disease (GCKD), and medullary cystic kidney disease type 2 (MCKD-2).Tamm-Horsfall Protein (THP) mediates the formation of mucous coat of the bladder, thereby regulating the permeability of the ascending loop of Henle. THP is known to adhere to Escherichia coli strains with type 131 and type S32 fimbriae, thereby blocking their interaction with the uroepithelium. Additionally, THP activates cells by directly signaling through Toll-like receptor 4 (TLR4). It has been demonstrated that THP stimulates the production of tumor necrosis factor-alpha (TNF-α) and tissue factor in monocytes through TLR4.
Physical form
Lyophillized from deionized water containing 0.02% sodium azide.
Storage and Stability
Store +2-8°C for up to 3 months after date of receipt.
DO NOT FREEZE.
DO NOT FREEZE.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Innate immunity and the kidney
Opal SM
Critical Care Nephrology, 476-482 (2019)
Marcus D Säemann et al.
The Journal of clinical investigation, 115(2), 468-475 (2005-01-15)
Tamm-Horsfall glycoprotein (THP) is expressed exclusively in the kidney and constitutes the most abundant protein in mammalian urine. A critical role for THP in antibacterial host defense and inflammatory disorders of the urogenital tract has been suggested. We demonstrate that
Urinary tract infections and the mucosal immune system
Ambite Ines, et al.
Mucosal Immunology, 2039-2058 (2015)
Mi-Na Lee et al.
Annals of laboratory medicine, 33(4), 293-296 (2013-07-05)
Familial juvenile hyperuricemic nephropathy (FJHN; OMIM 162000) is an autosomal dominant disorder characterized by hyperuricemia and gouty arthritis due to reduced kidney excretion of uric acid and progressive renal failure. Gradual progressive interstitial renal disease, with basement membrane thickening and
Noel Edwards et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 32(12), 1994-1999 (2017-06-13)
Heterozygous mutations in UMOD encoding the urinary protein uromodulin are the most common genetic cause of autosomal dominant tubulointerstitial kidney disease (ADTKD). We describe the exceptional case of a patient from a consanguineous family carrying a novel homozygous UMOD mutation
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