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5.08839

Sigma-Aldrich

BIBR1532

≥98% (HPLC), solid, telomerase inhibitor, Calbiochem®

Synonym(s):

Telomerase Inhibitor X, BIBR1532, BIBR 1532, BIBR-1532

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About This Item

Empirical Formula (Hill Notation):
C21H17NO3
CAS Number:
Molecular Weight:
331.36
UNSPSC Code:
12352200
NACRES:
NA.77

Pricing and availability is not currently available.

product name

Telomerase Inhibitor X, BIBR1532,

Assay

≥98% (HPLC)

Quality Level

form

solid

potency

93 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 100 mg/mL

storage temp.

2-8°C

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This Item
31137533737401-6100
assay

99%

assay

≥99.0%

assay

≥99.95% trace metals basis

assay

-

vapor pressure

1 mmHg ( 49 °C)

vapor pressure

1 mmHg ( 49 °C)

vapor pressure

1 mmHg ( 49 °C)

vapor pressure

-

mp

73.4 °C (lit.)

mp

73.4 °C (lit.)

mp

73.4 °C (lit.)

mp

-

vapor density

7.9 (vs air)

vapor density

7.9 (vs air)

vapor density

7.9 (vs air)

vapor density

-

product line

ReagentPlus®

product line

-

product line

-

product line

-

General description

A cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC50 = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.
A cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC50 = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Teomerase
Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Damm, K., et al. 2001. The. EMBO J.20, 6958.
Pascolo, E., et al. 2002. J. Biol. Chem.277,15566.

Nakashima, M., et al. 2013. J. Biol. Chem.288, 33171.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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