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Key Documents

05-246

Sigma-Aldrich

Anti-Integrin α1 Antibody, clone 5E8D9

clone 5E8D9, Upstate®, from mouse

Synonym(s):

Anti-CD49a, Anti-VLA1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

5E8D9, monoclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
neutralization: suitable

isotype

IgG2a

NCBI accession no.

NM_181501

UniProt accession no.

P56199

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... ITGA1(3672)

Specificity

integrinα1

Immunogen

Purified human integrinα1

Application

Anti-Integrin α1 Antibody, clone 5E8D9 is an antibody against Integrin α1 for use in IC, NEUT.
Research Category
Cell Structure
Research Sub Category
Integrins

Quality

routinely evaluated on cold ethanol fixed cells in immunocytochemistry

Target description

150kDa

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl
Format: Purified
Protein A chromatography

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Functional regulation of the human integrin VLA-1 (CD49a/CD29) by divalent cations and stimulatory beta 1 antibodies.
Luque, A, et al.
Febs Letters, 346, 278-284 (1994)
Regulation of the VLA integrin-ligand interactions through the beta 1 subunit.
Arroyo, A G, et al.
The Journal of cell biology, 117, 659-670 (1992)
S Makihira et al.
The Journal of biological chemistry, 274(16), 11417-11423 (1999-04-10)
Cartilage matrix protein (CMP; also known as matrilin-1), one of the major noncollagenous proteins in most cartilages, binds to aggrecan and type II collagen. We examined the effect of CMP on the adhesion of chondrocytes and fibroblasts using CMP-coated dishes.
Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by alpha3beta1 integrin and regulated by insulin-like growth factor-1 and CD98.
S Chandrasekaran, N H Guo, R G Rodrigues, J Kaiser, D D Roberts
The Journal of Biological Chemistry null
M A Sanders et al.
The Journal of biological chemistry, 275(48), 38040-38047 (2000-09-15)
Integrin-initiated extracellular signal-regulated kinase (ERK) activation by matrix adhesion may require focal adhesion kinase (FAK) or be FAK-independent via caveolin and Shc. This remains controversial for fibroblast and endothelial cell adhesion to fibronectin and is less understood for other matrix
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