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C-022

Supelco

Chlordiazepoxide solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C16H14ClN3O
CAS Number:
58-25-3
Molecular Weight:
299.75
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

CNC1=C[N+]([O-])=C(c2ccccc2)c3cc(Cl)ccc3N1

InChI

1S/C16H14ClN3O/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15/h2-10,18-19H,1H3

InChI key

VVMUANXXDBQGMO-UHFFFAOYSA-N

General description

Chlordiazepoxide is a benzodiazepine sold under trade names such as Librax® or Klopoxid for short-term treatment of anxiety or management of acute alcohol withdrawal syndrome. This certified solution standard is suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from forensic analysis and clinical toxicology to urine drug testing and pharmaceutical research.

Application


  • Chlordiazepoxide hydrochloride in psychopharmacology: This research chemical is primarily used to investigate the pharmacokinetics and metabolic pathways of benzodiazepines. Studies such as those by Shayesteh et al. have explored the dissociation constants of benzodiazepines, aiding in the development of more effective anxiolytic treatments with a focus on minimizing side effects (Shayesteh et al., 2015).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Librax is a registered trademark of Valeant Pharmaceuticals North America LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ahmed T Hussin et al.
Neuropharmacology, 63(5), 883-889 (2012-07-04)
The effects of the anxiolytic drug chlordiazepoxide (CDZ) on general activity and anxiety-related behaviour of male and female Swiss-Webster mice were investigated in the triple test, which combines the open field (OF), elevated-plus maze (EPM) and the light-dark box (LDB).
Mark Galizio et al.
Psychopharmacology, 225(2), 397-406 (2012-08-25)
A number of tasks are used to assess working memory in rodents, but the odor span task (OST) is unique in studying performance as a function of the number of stimuli to remember. The purpose of the present study was
Julian C Leslie et al.
Psychopharmacology, 223(2), 223-235 (2012-04-25)
Effects on the extinction of GABAergic drug, chlordiazepoxide (CDP), and glutamatergic drug, D: -cycloserine (DCS), in C57BL/6 mice were compared. Following a palatability test (Experiment 1), Experiments 2-6 involved food-reinforced lever press training followed by extinction sessions at 1- or
Line V Kristensen et al.
Journal of neurochemistry, 121(3), 373-382 (2012-02-24)
Several metabolic neuroimaging studies have indicated that bipolar patients with mania exhibit alterations in metabolic activity, suggesting that perturbations in corticolimbic function contribute to the functional deficits associated with the disease. Because pharmacological stimulation of K(v)7 channel function has shown
O M Husain et al.
QJM : monthly journal of the Association of Physicians, 106(1), 43-49 (2012-09-29)
Alcohol-related presentations to hospital have been increasing in the UK in recent years, including the occurrence of acute withdrawal. This study sought to better characterize the clinical features, patterns of treatment and outcomes in this patient group. Patients admitted to
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