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850345C

Avanti

14:0 PC (DMPC)

1,2-dimyristoyl-sn-glycero-3-phosphocholine, chloroform

Synonym(s):

1,2-ditetradecanoyl-sn-glycero-3-phosphocholine; DMPC; PC(14:0/14:0)

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About This Item

Empirical Formula (Hill Notation):
C36H72NO8P
CAS Number:
Molecular Weight:
677.93
UNSPSC Code:
51191904
NACRES:
NA.25

Pricing and availability is not currently available.

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (850345C-25mg)
pkg of 1 × 20 mL (850345C-500mg)
pkg of 2 × 20 mL (850345C-1g)
pkg of 2 × 4 mL (850345C-200mg)

manufacturer/tradename

Avanti Research - A Croda Brand 850345C

concentration

10 mg/mL (850345C-25mg)
25 mg/mL (850345C-1g)
25 mg/mL (850345C-200mg)
25 mg/mL (850345C-500mg)

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C36H72NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-35(38)42-32-34(33-44-46(40,41)43-31-30-37(3,4)5)45-36(39)29-27-25-23-21-19-17-15-13-11-9-7-2/h34H,6-33H2,1-5H3/t34-/m0/s1

InChI key

CITHEXJVPOWHKC-UMSFTDKQSA-N

General description

Phosphatidylcholine (PC) is a strong bilayer-forming lipid. It the most common phospholipid in mammalian membranes.[1] It is also an important component of the mucosal layer of the colon.[2]
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

14:0 PC (DMPC) has been used in liposome preparation.[3] It is also suitable for use:
  • in the preparation of lipid bicelles for nuclear magnetic resonance (NMR) experiments[4]
  • in labeled vesicle preparation for fluorescence polarization measurements[5]
  • as internal standard (IS) for the quantitation of phosphatidylcholine (PC) by liquid chromatography with tandem mass spectrometry (LC-MS-MS)[6]

Biochem/physiol Actions

Phosphatidylcholine (PC) functions as a surfactant within the mucus to form a hydrophobic surface to inhibit bacterial penetrance.[2] It is used to treat fat embolism. Phosphatidylcholine lowers the levels of cholesterol and triglycerides.[7]

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (850345C-1g)
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (850345C-500mg)
5 mL Clear Glass Sealed Ampule (850345C-200mg)
5 mL Clear Glass Sealed Ampule (850345C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash


  • Certificates of Analysis (COA)

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    The acceleration of implant osseointegration by liposomal Wnt3a
    Popelut A, et al.
    Biomaterials, 31(35), 9173-9181 (2010)
    In vitro Membrane Interaction and Liposome Fusion Assays Using Recombinant Hepatitis C Virus Envelope Protein E2
    Yelamos B, et al.
    Biochimica et biophysica acta. General subjects (2018)
    The Membranes of Cells (2016)
    Integrative Medicine - E-Book (2017)
    Lipid binding by disordered proteins
    Perez Y, et al.
    Protocol Exchange, 10 (2013)

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