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A79604

Sigma-Aldrich

4-Aminosalicylic acid

99%, for peptide synthesis

Synonym(s):

4-Amino-2-hydroxybenzoic acid, PAS

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About This Item

Linear Formula:
H2NC6H3-2-(OH)CO2H
CAS Number:
65-49-6
Molecular Weight:
153.14
Beilstein:
473071
EC Number:
200-613-5
MDL number:
MFCD00007789
UNSPSC Code:
12352106
PubChem Substance ID:
24891299
NACRES:
NA.22
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Product Name

4-Aminosalicylic acid, 99%

Quality Level

200

Assay

99%

form

powder

reaction suitability

reaction type: solution phase peptide synthesis

color

white to beige

mp

135-145 °C (lit.)

application(s)

peptide synthesis

SMILES string

Nc1ccc(C(O)=O)c(O)c1

InChI

1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)

InChI key

WUBBRNOQWQTFEX-UHFFFAOYSA-N

Gene Information

human ... PTPN1(5770)

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Application

4-Aminosalicylic acid (4-ASA) can be used in the synthesis of:
  • Azo derivatives of 4-ASA with anti-inflammatory effects.[1]
  • Ammonium 4-aminosalicylate salt polymorphs which are used as pharmaceutical ingredients.[2]
  • Salicylic acid-triazole analogs which are used as quorum sensing inhibitors against Pseudomonas aeruginosa.[3]

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL6747
BCCF7304
BCCD3897
BCCC1939
BCBZ8103

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Synthesis of azo derivatives of 4-aminosalicylic acid.
Zhao ZB, et al.
Chinese Chemical Letters = Zhongguo Hua Xue Kuai Bao, 18(6), 639-642 (2007)
Design, Synthesis and Biological Evaluation of Triazole-Containing 2-Phenylindole and Salicylic Acid as Quorum Sensing Inhibitors Against Pseudomonas aeruginosa.
Srinivasarao S, et al.
ChemistrySelect, 3(32), 9170-9180 (2018)
Polymorphic ammonium salts of the antibiotic 4-aminosalicylic acid.
Andre V, et al.
Crystal Growth & Design, 12(6), 3082-3090 (2012)
Maria João Forjaz et al.
Movement disorders : official journal of the Movement Disorder Society, 30(4), 545-551 (2014-12-30)
The Parkinson Anxiety Scale is a new scale developed to measure anxiety severity in Parkinson's disease specifically. It consists of three dimensions: persistent anxiety, episodic anxiety, and avoidance behavior. This study aimed to assess the measurement properties of the scale
Tian-Loon Lee et al.
Journal of glaucoma, 23(9), 644-648 (2013-02-23)
To determine the incidence of intraocular pressure (IOP) spikes within the first 30 minutes after sequential argon-Nd:YAG laser peripheral iridotomy (LPI) in patients with angle closure and to explore risk factors for their occurrence. A total of 428 consecutive eyes
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Questions

1–2 of 2 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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