746061

Difluoromethyl 2-pyridyl sulfone

97% (HPLC)

• Synonym(s): 2-[(Difluoromethyl)sulfonyl]pyridine, Hu Reagent, 2-(Difluoromethylsulfonyl)pyridine, 2-PySO₂CF₂H
• Empirical Formula (Hill Notation): C₆H₅F₂NO₂S
• CAS Number: 1219454-89-3
• Molecular Weight: 193.17
• Beilstein: 20317604
• MDL number: MFCD17010193
• UNSPSC Code: 12352101
• PubChem Substance ID: 329765740
• NACRES: NA.22

Properties

• Assay: 97% (HPLC)
• form: solid
• mp: 44-49 °C
• functional group: fluoro; sulfone
• SMILES string: O=S(C1=CC=CC=N1)(C(F)F)=O
• InChI: 1S/C6H5F2NO2S/c7-6(8)12(10,11)5-3-1-2-4-9-5/h1-4,6H
• InChI key: YRQNSTAWTLXCEZ-UHFFFAOYSA-N

Description

General description

Difluoromethyl 2-pyridyl sulfone (2-PySO₂CF₂H) is a reagent used in the gem-difluoroolefination of aldehydes and ketones. It is also used as a reagent in the nucleophilic difluoro(sulfonato)methylation of alcohols, N-sulfinyl imines, and halides.

Application

Reagent is used in the olefination of ketones and aldehydes to form gem-difluoro olefins under basic conditions. Product is also used as a crucial intermediate toward making 1,1-difluorinated alkyl chains for the alkylation of heterocycles.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301,H319
• Precautionary Statements: P264 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable