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741884

Sigma-Aldrich

Poly(2-ethyl-2-oxazoline)

average Mn 20,000, PDI <1.4

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

Quality Level

100

mol wt

average Mn 20,000

mp

>300 °C

PDI

<1.4

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Application

This Poly(2-ethyl-2-oxazoline) polymer is amorphous and water soluble with good temperature stability. Jordan and coworkers showed biocompatibility, no accumulation in tissue, and rapid clearance from the bloodstream1. End-group modified poly(2-ethyl-2-oxazoline)s have been conjugated to peptides2, and were shown as versatile alternatives to poly(ethylene glycol) (PEG) for both protein and small drug conjugation3.

Potential substitute for poly(vinyl alcohol) and poly(vinyl pyrrolidone). Sometimes it is used as an adhesion promoter in coatings. This is also sometimes used in heat sealing and remoistenable hot-melt adhesives. N-propionyl substituted linear polyethylenimine

Features and Benefits

Nonionic, water-soluble thermoplastic. Better heat stability than poly(vinyl alcohol). Good melt flow, shear stability and Newtonian characteristics. Water is a room temperature Theta solvent.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCM9423
MKCT4282
MKCN6793
MKCN0937
MKCJ0488

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F. C. Gaertner, R. Luxenhofer, B. Blechert, R. Jordan, M. Essler
J. Controlled Release, 119, 291-300 (2007)
R. Luxenhofer, M. Lopez-Garcia, A. Frank, H. Kessler, R. Jordan
Polym. Mater. Sci. Eng., 95, 283-284 (2006)
A. Mero, G. Pasut, L. D. Via, M.W. M. Fijten, et al.
J. Controlled Release, 125, 87-95 (2008)
Yung-Chu Chen et al.
Journal of biomedical materials research. Part A, 100(5), 1279-1292 (2012-03-01)
The multifunctional nanoparticles constructed from triphenylamine-poly(lactide-co-glycolide)-poly(ethyleneglycol)-poly(lactide-co-glycolide) (TPA-PEP) and folate-poly(2-ethyl-2oxazoline)-poly(D,L-lactide) (folate-PEOz-PLA) were developed in this study. Iron oxide nanoparticles (IOP) and paclitaxel (PTX) were coencapsulated in the nanoparticles with diameter less than 200 nm. The drug-loaded nanoparticles emit fluorescence peak at
Issa Katime et al.
Applied spectroscopy, 57(7), 829-834 (2003-12-09)
This paper reports an FT-IR study of blends of poly(mono-n-alkyl itaconates) with poly(N,N-dimethylacrylamide) (PDMA) and poly(ethyloxazoline) (PEOX). Strong hydrogen bonding has been found, and both polybases have shown similar acceptor strengths. Derivative techniques show asymmetric profiles for the free carbonyl
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Poly(2-oxazoline)s (POx) in Biomedical Applications

Poly(2-oxazoline)s, synthesized via LCROP, resemble polypeptides and have various applications in polymer chemistry.

Poly(2-oxazoline)s (POx) in Biomedical Applications

Poly(2-oxazoline)s, synthesized via LCROP, resemble polypeptides and have various applications in polymer chemistry.

Poly(2-oxazoline)s (POx) in Biomedical Applications

Poly(2-oxazoline)s, synthesized via LCROP, resemble polypeptides and have various applications in polymer chemistry.

Poly(2-oxazoline)s (POx) in Biomedical Applications

Poly(2-oxazoline)s, synthesized via LCROP, resemble polypeptides and have various applications in polymer chemistry.

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