549835
2,4,6-Tris(dimethylamino)-1,3,5-triazine
96%
Synonym(s):
Altretamine, Hexamethylmelamine
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About This Item
Empirical Formula (Hill Notation):
C9H18N6
CAS Number:
Molecular Weight:
210.28
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Assay
96%
mp
171-175 °C (lit.)
functional group
amine
SMILES string
CN(C)c1nc(nc(n1)N(C)C)N(C)C
InChI
1S/C9H18N6/c1-13(2)7-10-8(14(3)4)12-9(11-7)15(5)6/h1-6H3
InChI key
UUVWYPNAQBNQJQ-UHFFFAOYSA-N
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General description
2,4,6-Tris(dimethylamino)-1,3,5-triazine exhibits antitumor activity.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Triazines and related products. Part 26. Synthesis and chemistry of bicyclic analogues of the antitumour drug 2, 4, 6-tris (dimethylamino)-1, 3, 5-triazine (hexamethylmelamine).
Langdon SP, et al.
Journal of the Chemical Society. Perkin Transactions 1, 993-998 (1984)
Nina Keldsen et al.
Gynecologic oncology, 88(2), 118-122 (2003-02-15)
To evaluate the activity of oral Altretamine in women with epithelial ovarian carcinoma who responded (PR or CR) to first line chemotherapy but relapsed within 6 months. The protocol was later amended to include patients with relapse within 12 months.
R T Zon et al.
Investigational new drugs, 19(3), 229-231 (2001-09-20)
Thirty patients with advanced renal cell carcinoma were treated on a phase 11 trial with altretamine. Altretamine was administered orally at a dosage of 260 mg/m2 days 1 through 14 with cycles repeated every 28 days. Nausea and vomiting were
M Hariharan et al.
Journal of microencapsulation, 19(1), 95-109 (2002-01-29)
Biodegradable poly(D,L-lactic acid) (PLA) microspheres containing hexamethylmelamine (HMM) were developed for potential use in chemoembolization and intraperitoneal implantation. The emulsion-solvent-evaporation/extraction method was used to prepare 15 formulations with different drug/polymer ratios, solvent compositions and emulsifer concentrations in the continuous aqueous
Lessons from a time capsule: evolution, not revolution, in therapy for advanced non-small-cell lung cancer.
Mark R Green
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 26(19), 3112-3113 (2008-07-02)
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