408166
1-(2-Pyridyl)piperazine
≥99%
Synonym(s):
2-Piperazinopyridine
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About This Item
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Quality Level
Assay
≥99%
form
liquid
refractive index
n20/D 1.595 (lit.)
bp
120-122 °C/2 mmHg (lit.)
density
1.072 g/mL at 25 °C (lit.)
SMILES string
C1CN(CCN1)c2ccccn2
InChI
1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2
InChI key
GZRKXKUVVPSREJ-UHFFFAOYSA-N
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General description
1-(2-Pyridyl)piperazine is a piperazine derivative.
Application
1-(2-Pyridyl)piperazine may be employed as reagent for the determination of both aliphatic and aromatic isocyanates in air by reversed-phase HPLC., It may be employed as reagent for the fluorometric determination of airborne diisocyantes.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
230.0 °F - closed cup
Flash Point(C)
110 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Determination of atmospheric isocyanate concentrations by high-performance thin-layer chromatography using 1-(2-pyridyl) piperazine reagent.
Analyst, 106(1258), 85-93 (1981)
Absorption and fluorescence of 1-(2-pyridyl)-piperazine and four diisocyanate derivatives in solution.
Journal of Photochemistry and Photobiology A: Chemistry, 107(1), 159-164 (1997)
Determination of trace atmospheric isocyanate concentrations by reversed-phase high-performance liquid chromatography using 1-(2-pyridyl) piperazine reagent.
Journal of Chromatography A, 212(1), 93-104 (1981)
European journal of pharmacology, 134(1), 113-116 (1987-01-28)
We investigated in mice the effects of one of the principal metabolites of buspirone and gepirone, 1-(2-pyridinyl)-piperazine (1-PmP), on hypothermia and reduced locomotion induced by clonidine (0.25 and 0.06 mg/kg, respectively), tests related to brain alpha-adrenergic function. Both effects were
Drug metabolism and disposition: the biological fate of chemicals, 35(8), 1387-1392 (2007-05-15)
The pharmacokinetics and in vivo potency of 6-hydroxybuspirone (6-OH-buspirone), a major metabolite of buspirone, were investigated. The plasma clearance (47.3 +/- 3.5 ml/min/kg), volume of distribution (2.6 +/- 0.3 l/kg), and half-life (1.2 +/- 0.2 h) of 6-OH-buspirone in rats
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