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Merck

390593

Sigma-Aldrich

1-(1-Adamantyl)ethylamine hydrochloride

99%

Synonym(s):

α-Methyltricyclo[3.3.1.13,7]-decane-1-methanamine hydrochloride, Rimantadine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H21N · HCl
CAS Number:
Molecular Weight:
215.76
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

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Quality Level

Assay

99%

mp

>300 °C (lit.)

functional group

amine

SMILES string

Cl.C[C@H](N)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2

InChI

1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H/t8?,9-,10+,11-,12-;

InChI key

OZBDFBJXRJWNAV-MZHJCFSPSA-N

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Pictograms

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Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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G G U Rohde
Der Internist, 52(9), 1047-1052 (2011-08-03)
Influenza infections have important socio-economic consequences. Risk groups identified so far include small children and elderly adults with comorbidities. In recent years in addition to seasonal influenza an outbreak of avian influenza occurred in 2005 and the new H1N1 pandemic
V G Belolipetskaia et al.
Eksperimental'naia i klinicheskaia farmakologiia, 74(7), 38-40 (2011-09-08)
Comparative pharmacokinetics of anti-influenza drug composition Antigrippin-maximum administered in capsules and a powder for preparing solutions has been studied after single administraton in a group of 18 healthy volunteers. Both preparations [manufactured by the Antiviral Research and Production Corporation (St
Georgina Cirrincione-Dall et al.
Journal of clinical pharmacology, 52(8), 1255-1264 (2011-11-01)
Preclinical data suggest increased antiviral activity and less viral resistance when neuraminidase inhibitors and adamantanes are used in combination to harness the complementary effects of their different mechanisms of action. Healthy volunteers were randomized to 5-day oral treatment with oseltamivir
Antiviral drugs for influenza.
The Medical letter on drugs and therapeutics, 54(1381), 1-3 (2012-01-12)
Rafal M Pielak et al.
Structure (London, England : 1993), 19(11), 1655-1663 (2011-11-15)
The M2 channel of influenza A is a target of the adamantane family antiviral drugs. Two different drug-binding sites have been reported: one inside the pore, and the other is a lipid-facing pocket. A previous study showed that a chimera

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