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261394

Sigma-Aldrich

1,1-Dimethylurea

99%

Synonym(s):

N,N-Dimethylurea

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About This Item

Linear Formula:
(CH3)2NCONH2
CAS Number:
Molecular Weight:
88.11
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

99%

form

solid

mp

178-183 °C (lit.)

solubility

water: soluble 5%, clear, colorless

functional group

amine

SMILES string

CN(C)C(N)=O

InChI

1S/C3H8N2O/c1-5(2)3(4)6/h1-2H3,(H2,4,6)

InChI key

YBBLOADPFWKNGS-UHFFFAOYSA-N

Gene Information

human ... EPHX2(2053)
mouse ... Ephx2(13850)

General description

Nonlinear optical properties of 1,1-dimethylurea (N,N′ dimethylurea), have been evaluated through second-harmonic generation.

Application

1,1-Dimethylurea (N,N-dimethylurea) has been used in the Dowex-50W ion exchange resin-promoted synthesis of N,N′-disubstituted-4-aryl-3,4-dihydropyrimidinones.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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K Yamada et al.
Acta endocrinologica, 128(4), 379-384 (1993-04-01)
We investigated the effect of free radical scavengers on the actions of cytokines on islet cells. Interferon-gamma and tumor necrosis factor-alpha reduced the nicotinamide adenine dinucleotide content of mouse islet cells; the combination of interferon-gamma (4 x 10(5) U/l) and
S Sandler et al.
Endocrinology, 124(3), 1492-1501 (1989-03-01)
This study aimed at a more detailed characterization of the mechanisms by which interleukin 1 (IL-1) inhibits insulin secretion. For this purpose, isolated rat pancreatic islets were kept in tissue culture for 5 days in medium RPMI 1640 plus 10%
Wanli Lu et al.
Chemistry & biology, 18(4), 425-431 (2011-04-26)
Pactamycin, one of the most densely functionalized aminocyclitol antibiotics, has pronounced antibacterial, antitumor, antiviral, and antiplasmodial activities, but its development as a clinical drug was hampered by its broad cytotoxicity. Efforts to modulate the biological activity by structural modifications using
C J Beehler et al.
The Journal of laboratory and clinical medicine, 123(1), 73-80 (1994-01-01)
Dimethylthiourea (DMTU) is a small, highly diffusible molecule that effectively scavenges toxic oxygen metabolites in vitro and reduces oxidative injury in many biologic systems. Nonetheless, for unknown reasons, DMTU has occasionally failed to decrease damage in some systems where injury
G P Meshram et al.
Mutation research, 279(4), 275-280 (1992-06-16)
Methyl isocyanate (MIC) in aqueous solution forms methylamine (MA) and N,N'-dimethylurea (DMU). MA in buffered system further converts into its salt form, methylamine hydrochloride (MAH). Therefore, MAH and DMU were evaluated for their mutagenic activity in the in vitro Ames

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