219428

4-Fluoroiodobenzene

99%

• Synonym(s): 1-Fluoro-4-iodobenzene, 1-Iodo-4-fluorobenzene, 4-Fluoro-1-iodobenzene, 4-Fluorophenyl iodide, 4-Iodo-1-fluorobenzene, 4-Iodofluorobenzene, p-Fluoroiodobenzene, p-Fluorophenyl iodide, p-Iodofluorobenzene
• Linear Formula: FC₆H₄I
• CAS Number: 352-34-1
• Molecular Weight: 222.00
• EC Number: 206-522-7
• MDL number: MFCD00001052
• UNSPSC Code: 12352100
• PubChem Substance ID: 24853127
• NACRES: NA.22

Properties

• Assay: 99%
• form: liquid
• contains: copper as stabilizer
• refractive index: n20/D 1.583 (lit.)
• bp: 182-184 °C (lit.)
• mp: −20 °C (lit.)
• density: 1.925 g/mL at 25 °C (lit.)
• functional group: fluoro; iodo
• SMILES string: Fc1ccc(I)cc1
• InChI: 1S/C6H4FI/c7-5-1-3-6(8)4-2-5/h1-4H
• InChI key: KGNQDBQYEBMPFZ-UHFFFAOYSA-N

Description

General description

4-[¹⁸F] Fluoroiodobenzene is a versatile building block in ¹⁸F radiochemistry and is used in various transition metal-mediated C-C and C-N cross-coupling reactions. Cross-coupling reaction of 4-fluoroiodobenzene with potassium pentafluorophenyltrifluoroborate in the presence of different palladium catalysts and silver oxide in toluene has been investigated.

Application

4-Fluoroiodobenzene was used in the preparation of fluorotriphenylene derivatives.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): 154.4 °F - closed cup
• Flash Point(C): 68 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves