143049

Aldrithiol^™-2

98%

• Synonym(s): 2,2′-Dithiodipyridine, 2,2′-Dipyridyl disulfide
• Empirical Formula (Hill Notation): C₁₀H₈N₂S₂
• CAS Number: 2127-03-9
• Molecular Weight: 220.31
• Beilstein: 154629
• EC Number: 218-343-1
• MDL number: MFCD00006287
• UNSPSC Code: 12352100
• PubChem Substance ID: 24848570
• NACRES: NA.22

Properties

• Assay: 98%
• form: solid
• mp: 56-58 °C (lit.)
• solubility: methanol: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow
• functional group: disulfide
• storage temp.: 2-8°C
• SMILES string: S(Sc1ccccn1)c2ccccn2
• InChI: 1S/C10H8N2S2/c1-3-7-11-9(5-1)13-14-10-6-2-4-8-12-10/h1-8H
• InChI key: HAXFWIACAGNFHA-UHFFFAOYSA-N

Description

General description

Aldrithiol^™-2 is a nucleocapsid zinc finger targeting compound and can abrogate the infectivity of human immunodeficiency virus type-1 virions. It is a thiol reagent.

Application

Aldrithiol^™-2 was used in the synthesis of adenosine-5′-phosphoimidazolide. It was employed with PPh₃ as a condensing agent in the amidation of carboxylic acid enantiomers for HPLC separation.

Thiol reagent. Employed with PPh₃ as a condensing agent in the amidation of carboxylic acid enantiomers for HPLC separation.

Legal Information

Aldrithiol is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves