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HPA050204

Sigma-Aldrich

Anti-SYNE2 antibody produced in rabbit

enhanced validation

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-DKFZP434H2235, Anti-KIAA1011, Anti-NUA, Anti-NUANCE, Anti-Nesp2, Anti-Nesprin-2, Anti-SYNE-2

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

independent
Learn more about Antibody Enhanced Validation

technique(s)

immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:500-1:1000

immunogen sequence

GTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQ

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SYNE2(23224)

General description

Spectrin repeat containing nuclear envelope protein 2 (SYNE2) was formerly known as nuclear envelope spectrin repeat protein (Nesprin-2), NUANCE and KASH (is an acronym for Klarsicht, ANC-1, Syne Homology) domain containing protein 2. The gene SYNE2 is localised on human chromosome on 14q23.2.

Immunogen

spectrin repeat containing, nuclear envelope 2

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-SYNE2 antibody recognises SYNE2 protein.

Biochem/physiol Actions

Spectrin repeat containing nuclear envelope protein 2 (SYNE2) is involved in nuclear positioning in the multi-nucleated skeletal muscles in the early developmental stage. SYNE2 is a part of the linker of nucleoskeleton and cytoskeleton (LINC) complex and is essential for connecting the nucleus to the cytoskeleton and other organelles. SYNE2 complexes with SUN2 of SUN proteins (Sad1 and UNC-84) and binds to F-actin to form transmembrane actin-associated nuclear (TAN) lines for actin-dependent nuclear movement. SYNE2 as a KASH domain protein, is involved in nuclear anchorage and migration. SYNE2 is essential for normal development of retina. Mutations in SYNE2 may cause retinal problems in photoreceptors, secondary neurons and muller glia. SYNE2 facilitates ciliogenesis in humans, which is necessary for numerous functions in the human including determining the left and right handedness.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST87551

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton
Dawe JR, et al.
Journal of Cell Science, 122(15), 2716-2726 (2009)
KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development
Yu J, et al.
Human Molecular Genetics, 20(6), 1061-1073 (2010)
A Mutation in Syne2 Causes Early Retinal Defects in Photoreceptors, Secondary Neurons, and Muller Glia
Maddox DM, et al.
Investigative Ophthalmology & Visual Science, 56(6), 3776-3787 (2015)
Characterization of gene rearrangements resulted from genomic structural aberrations in human esophageal squamous cell carcinoma KYSE150 cells
Hao JJ, et al.
Gene, 513(1), 196-201 (2013)
Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation
Zhang X, et al.
Development, 134(5), 901-908 (2007)

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