NIST3949
Folate Vitamers in Frozen Human Serum
NIST®SRM®
Synonym(s):
Serum xx
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About This Item
UNSPSC Code:
41116107
NACRES:
NA.24
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Recommended Products
grade
certified reference material
packaging
pkg of 3.072 g
manufacturer/tradename
NIST®
technique(s)
mass spectrometry (MS): suitable
application(s)
clinical testing
format
matrix material
storage temp.
-65 to -96°C
General description
A unit of the Folate Vitamers standard reference material (SRM) 3949 consists of one vial each of three materials: low (Level 1), medium (Level 3), and high (Level 2) folates. Each vial contains approximately 1.0 mL of frozen human serum.
SRM_3949_cert
SRM_3949_SDS
SRM_3949_cert
SRM_3949_SDS
Application
Folate Vitamers standard reference material (SRM) is intended for use in validating methods for determining folate vitamers in human serum, and for qualifying the in-house control materials analyzed using those methods.
Preparation Note
- SRM 3949 is provided as a set of three vials of frozen serum that should be allowed to thaw at room temperature for at least 30 min under subdued light.
- The contents of a vial should then be gently mixed prior to the removal of a test portion for analysis.
- Precautions should be taken to avoid exposure to strong ultraviolet (UV) light and direct sunlight.
Other Notes
- SRM 3949 is intended for research use.
- Details on expiration, storage, safety, usage, and source are provided in the NIST certificate
- Information on biomaterials, disposal, and transport is available in the SDS
Legal Information
NIST is a registered trademark of National Institute of Standards and Technology
SRM is a registered trademark of National Institute of Standards and Technology
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Seok-Won Hyung et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1179, 122725-122725 (2021-07-27)
One predominant and bioactive folate vitamer circulating in the blood is 5-methyltetrahydrofolate (5-Me-THF). In this study, a method for the accurate determination of 5-Me-THF in human plasma samples of various volumes was established using isotope dilution ultra-high performance liquid chromatography-mass
Johanna E Camara et al.
Analytical and bioanalytical chemistry, 415(5), 809-821 (2022-12-13)
The US National Institute of Standards and Technology (NIST) developed a Standard Reference Material® (SRM®) 3949 Folate Vitamers in Frozen Human Serum to replace SRM 1955 Homocysteine and Folate in Human Serum. The presence of increased endogenous levels of folic
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