The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.
A cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC50 = 10 and 50 M in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50<10 M) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release.
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Packaged under inert gas
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Toxicity: Standard Handling (A)
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Cassidy-Stone A., et al. 2008. Dev. Cell14, 193.
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CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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11 - Combustible Solids
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WGK 3
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Not applicable
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Not applicable
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