361556

GSK-3 Inhibitor IX, Control, MeBIO

The GSK-3 Inhibitor IX, Control, MeBIO, also referenced under CAS 710323-61-8, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(s): GSK-3 Inhibitor IX, Control, MeBIO, 1-Methyl-BIO
• Empirical Formula (Hill Notation): C₁₇H₁₂BrN₃O₂
• CAS Number: 710323-61-8
• Molecular Weight: 370.20
• MDL number: MFCD09037537
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: dark red
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: Brc1cc2c(cc1)\C(=C3\Nc4c(cccc4)C\3N=O)\C(=O)N2C
• InChI: 1S/C17H12BrN3O2/c1-21-13-8-9(18)6-7-11(13)14(17(21)22)16-15(20-23)10-4-2-3-5-12(10)19-16/h2-8,15,19H,1H3/b16-14-
• InChI key: ATNXSIPNXWSMRK-PEZBUJJGSA-N

Description

General description

A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC₅₀ >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC₅₀ = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.

A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as an inactive control for Cdk1/cyclin B, Cdk5/p25, and GSK-3α/β (IC₅₀ >92 µM for Cdk1/cyclin B, >100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC₅₀ = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Relevant kinase inactive control

Product does not compete with ATP.

Reversible: no

Target IC₅₀: >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable