934801
Glycidol chitosan
Degree of functionalization > 80%
Synonym(s):
Dihydroxypropyl chitosan, Glycolchitosan, glycol chitosan
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About This Item
Linear Formula:
[C9H17NO6]n [C8H13NO5]m
UNSPSC Code:
12352201
NACRES:
NA.21
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General description
Chitosan is a cationic biodgradable and biocompatible biopolymer that has been commonly used in many applications. The polymer chains are positively charged when disolved in aqueous solutions of pH<6.5. However, the biomedical applications of the positively charged chitosan are limited becuase it cannot be easily dissolved in aqueous media. Glycidol chitosan is a derivative of chitosan whereby hydrohilic glycidol is grafted onto the amino groups of chitosan to improve its solubility in a wider range of pH. It possesses many useful biological properties such as biocompatibility, biodegradability, and antimicrobial properties. It can also be further functionalized to induce photo and thermally crosslinkable properites and can be used as a precursor for hydrogel preparations that can be used in many biomedical applications.
Application
- Hydrogels
- Tissue engineering
- Bioprinting
- Drug delivery system
Features and Benefits
- Naturally derived biopolymer
- Cationic
- Enhanced solubility
- Tunable precursor material
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Evaluation of the biological properties of soluble chitosan and chitosan microspheres
Carreno-Gomez, B
International Journal of Pharmaceutics, 148 (1997)
Glycol Chitosan: A Water-Soluble Polymer for Cell Imaging and Drug Delivery
Fengming Lin
Molecules (Basel), 24 (2009)
Chitosan chemistry and pharmaceutical perspectives
Kumar MR
Chemical Reviews, 104 (2004)
Modified chitosan hydrogels as drug delivery and tissue engineering systems: present status and applications
Tapan Kumar Giri
Acta Pharmaceutica Sinica. B, 2 (2012)
Jobanpreet Dhillon et al.
Journal of biomedical materials research. Part A, 107(3), 571-585 (2018-11-06)
Cell-based therapies involving the injection of adipose-derived stem/stromal cells (ASCs) within rationally designed biomaterials are a promising approach for stimulating angiogenesis. With this focus, the current work explored the effects of incorporating integrin-binding RGD or IKVAV peptides within in situ-gelling
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