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SAB4502234

Sigma-Aldrich

Anti-Cytochrome c antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CYC, CYCS, Cytochrome c

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 11 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P99999

UniProt accession no.

P99999

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CYCS(54205)

Related Categories

General description

Anti-Cytochrome c antibody detects endogenous levels of total Cytochrome c protein.
The cytochrome c gene is mapped to human chromosome 7p15.3. The encoded protein consists of two thioether present between heme and two cysteine residues included in a CXXCH motif (highly conserved). It is localized to mitochondrial intermembrane space.

Immunogen

The antiserum was produced against synthesized peptide derived from human Cytochrome c.

Immunogen Range: 10-59

Application

Anti-Cytochrome c, N-terminal antibody produced in rabbit has been used in western blot analysis.

Biochem/physiol Actions

Cytochrome c is a water-soluble intermediary of electron transport chain. It acts as an ROS (reactive oxygen species) scavenger, and involved in redox-mediated protein import and apoptosis. Cytochrome c has peroxidase activity, contributing towards intrinsic pathway of apoptosis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Josephs TM
The Biochemical Journal, 458(2), 259-265 (2014)
5'RUNX1-3'USP42 chimeric gene in acute myeloid leukemia can occur through an insertion mechanism rather than translocation and may be mediated by genomic segmental duplications.
Zagaria A
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Apobec2 deficiency causes mitochondrial defects and mitophagy in skeletal muscle.
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Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.
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Proceedings of the National Academy of Sciences of the USA, 111(41), 14782-14787 (2014)
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The goal of the current study was to clarify the potential molecular mechanism underlying the protective effects of silymarin (SIL) administration against diazinon-induced subacute nephrotoxicity, with a special emphasis on the role of the Kelch-like-associated protein-1 (Keap1)-nuclear factor erythroid 2-related
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