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SAB4100313

Sigma-Aldrich

Monoclonal Anti-LGALS3BP antibody produced in mouse

clone LGALS3BP-A265, culture supernatant

Synonym(s):

Anti-90K, Anti-BTBD17B, Anti-Lectin, galactoside-binding, soluble, 3 binding protein, Anti-MAC-2-BP

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

LGALS3BP-A265, monoclonal

form

aqueous solution

mol wt

antigen predicted mol wt 65.2 kDa

species reactivity

human

technique(s)

western blot: suitable

isotype

IgG1

UniProt accession no.

Q08380

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LGALS3BP(3959)

General description

Lectin galactoside-binding soluble 3 binding protein (LGALS3BP), a tumor-secreted antigen, is a large oligomeric and highly glycosylated protein. The LGALS3BP gene is located on human chromosome 17q25.

Immunogen

LGALS3BP purified recombinant protein

Biochem/physiol Actions

Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) also known as Mac-2 binding protein (M2BP) acts as a ligand of the lactose-specific S-type lectin, galectin-3. Mac-2 binding protein (M2BP) participates in cell adhesion and in tumor progression. Serum Mac-2 binding protein glycosylation isomer (M2BPGi) is considered as an important marker to study the criticality of liver disease.

Physical form

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Xiaoxin Zhang et al.
Cellular signalling, 63, 109359-109359 (2019-07-16)
Previous studies showed that lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is an important participant in tumor progression. However, its prognostic value and functional mechanism in oral squamous cell carcinoma (OSCC) are still unclear. In this study, we analyzed LGALS3BP
Tomonori Sugiura et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 29(12), 1337-1344 (2019-10-28)
Mac-2 binding protein (M2BP) plays an important role in cell adhesion. In a recent cross-sectional study we reported that serum M2BP concentrations may reflect silent atherosclerosis. The aim of the present prospective follow-up study was to investigate possible relationships between
G Calabrese et al.
Cytogenetics and cell genetics, 69(3-4), 223-225 (1995-01-01)
Levels of a 90-kDa tumor associated protein, designated 90K (gene symbol LGALS3BP), have been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). 90K appears to be implicated in immune
Lung-Yi Mak et al.
World journal of gastroenterology, 25(11), 1398-1408 (2019-03-29)
Liver cirrhosis is a major risk factor for hepatocellular carcinoma (HCC) development in chronic hepatitis B (CHB). Serum Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel serological marker for fibrosis. The role of M2BPGi in prediction of HCC is
Enza Piccolo et al.
Journal of translational medicine, 13, 248-248 (2015-07-30)
A previous report has shown that LGALS3BP (also known as 90K or Mac-2 BP) has antitumor activity in colorectal cancer (CRC) via suppression of Wnt signalling with a novel mechanism of ISGylation-dependent ubiquitination of β-catenin. The role of LGALS3BP in

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