PZ0176

SC-26196

≥98% (HPLC)

• Synonym(s): SC-26196, a,a-diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile; 2,2-diphenyl-5-(4-[[(1 E)-pyridin-3-yl-methylidene]amino]piperazin-1-yl)pentanenitrile
• Empirical Formula (Hill Notation): C₂₇H₂₉N₅
• CAS Number: 218136-59-5
• Molecular Weight: 423.55
• MDL number: MFCD11226148
• UNSPSC Code: 41121801
• PubChem Substance ID: 329823750
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: N#CC(CCCN1CCN(CC1)\N=C\c2cccnc2)(c3ccccc3)c4ccccc4
• InChI: 1S/C27H29N5/c28-23-27(25-10-3-1-4-11-25,26-12-5-2-6-13-26)14-8-16-31-17-19-32(20-18-31)30-22-24-9-7-15-29-21-24/h1-7,9-13,15,21-22H,8,14,16-20H2/b30-22+
• InChI key: QFYKXKMYVYOUNJ-JBASAIQMSA-N

Description

Application

SC-26196 has been used as an inhibitor of delta6 (Δ6) fatty acid desaturase:

• in mouse inner medullary collecting duct (IMCD3) and human (female) embryonic kidney (HEK) 293 cell culture as Dulbecco′s modified eagle′s medium (DMEM) component
• in hepatic HepG2 cells
• in glioblastoma cell lines to test its effect post-radiation treatments

Biochem/physiol Actions

SC-26196 is a Delta6 fatty acid desaturase (Delta6D) inhibitor. It specifically inhibited Delta6D activity with an IC(50) value of 100 nM. The rate-limiting step in arachidonic acid synthesis is the desaturation of dietary linoleic acid by Delta6D. SC-26196 completely prevented this conversion of linoleic acid to arachidonic acid.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable