Skip to Content
Merck
All Photos(3)

Key Documents

View All Documentation

P7561

Sigma-Aldrich

Phentolamine methanesulfonate salt

≥98% (TLC), powder

Synonym(s):

2-(N-[m-Hydroxyphenyl]-p-toluidinomethyl)imidazoline

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Linear Formula:
C17H19N3O · CH3SO3H
CAS Number:
65-28-1
Molecular Weight:
377.46
EC Number:
200-604-6
MDL number:
MFCD00134201
UNSPSC Code:
12352116
PubChem Substance ID:
24277798
NACRES:
NA.77

Quality Level

200

Assay

≥98% (TLC)

form

powder

color

white to off-white

mp

180-182 °C (lit.)

solubility

ethanol: 26 mg/mL
H2O: 50 mg/mL

originator

Novartis

SMILES string

CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3

InChI

1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)

InChI key

OGIYDFVHFQEFKQ-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

α-Adrenergic receptor antagonist; peripheral vasodilator.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Amanda M Wahl et al.
The Journal of physiology, 601(20), 4539-4556 (2023-09-19)
Currently, all salivary ducts (intercalated, striated and collecting) are assumed to function broadly in a similar manner, reclaiming ions that were secreted by the secretory acinar cells while preserving fluid volume and delivering saliva to the oral cavity. Nevertheless, there
Jérémie Joffre et al.
Critical care medicine, 49(3), e315-e326 (2021-01-23)
Catecholaminergic vasopressors are the cornerstone of circulatory shock management. Nevertheless, catecholamines have problematic side effects, arousing a growing interest in noncatecholaminergic agents such as vasopressin or angiotensin-II. However, their respective effects on sepsis-associated microvascular endothelial dysfunction such as permeability or
Darren P Casey et al.
Hypertension (Dallas, Tex. : 1979), 60(4), 1016-1022 (2012-09-06)
Aging is associated with increased retrograde and oscillatory shear in peripheral conduit arteries of humans. Although the mechanisms responsible for these age-related changes are not completely understood, augmented downstream α-adrenergic tone likely plays a significant role in this phenomenon. Therefore
Darren P Casey et al.
Journal of applied physiology (Bethesda, Md. : 1985), 113(8), 1201-1212 (2012-09-11)
We tested the hypothesis that elevated sympathetic tone is responsible for lower peak vasodilation after single muscle contractions in older adults. Young (n = 13, 7 men and 6 women, age: 27 ± 1 yr) and older (n = 13
K N Manolopoulos et al.
Diabetologia, 55(11), 3029-3037 (2012-08-18)
Fatty acid entrapment in femoral adipose tissue has been proposed to prevent ectopic fat deposition and visceral fat accumulation, resulting in protection from insulin resistance. Our objective was to test the hypothesis of femoral, compared with abdominal, adipose tissue resistance
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service