I8904
Insulin-like Growth Factor-II from mouse
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Synonym(s):
IGF-II
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Product Name
Insulin-like Growth Factor-II from mouse, IGF-II, recombinant, expressed in E. coli, lyophilized powder
biological source
mouse
recombinant
expressed in E. coli
Assay
>97% (SDS-PAGE)
form
lyophilized powder
quality
endotoxin tested
mol wt
~7.4 kDa
packaging
pkg of 5X50 μg
pkg of 50 μg
impurities
<1.0EUper1mg (LAL test)
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... IGF2(16002) , Igf2(16002)
General description
Recombinant Mouse IGF-II is produced from a DNA sequence encoding the mature IGF-II protein. Mouse IGF-II, a 67 amino acid protein, has a predicted molecular matrix of ~7.4 kDa. Mouse and human IGF-II share 91% sequence homology. Insulin-like growth factor II (also known as multiplication stimulating activity or MSA) and insulin-like growth factor I (IGF-I) belong to the family of insulin-like growth factors, which are structurally homologous to proinsulin. Mature IGF-I and IGF-II are highly conserved and share ~70% amino acid sequence identity. They have autocrine, paracrine, and endocrine functions.
Biochem/physiol Actions
Insulin-like growth factor II (IGF-II) is a potent mitogenic growth factor that mediates growth-promoting activities in embryonic development. IGF-II binds the IGF-II receptor with high affinity. IGF-I and IGF II are expressed in many tissues and cell types. IGF-II is mitogenic for a variety of cultured cells including human or chicken fibroblasts, mouse 3T3 cells, normal rat kidney.
Physical form
Lyophilized from a 0.2 μm filtered solution of 30% acetonitrile and 0.1% of TFA.
Analysis Note
The biological activity is measured in a serum-free cell proliferation assay using the human breast carcinoma cell line MCF-7.
related product
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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S D O'Dell et al.
The international journal of biochemistry & cell biology, 30(7), 767-771 (1998-09-02)
Insulin-like growth factor II (IGF-II) plays a key role in mammalian growth, influencing foetal cell division and differentiation and possibly metabolic regulation. The mature 67 amino acid peptide shares sequence homology with both insulin and IGF-I. The liver is the
Biyun Qian et al.
Oncology reports, 25(1), 203-213 (2010-11-27)
High expression of insulin-like growth factor-II (IGF-II) in epithelial ovarian cancer is associated with aggressive disease and poor prognosis. IGF-II transcription is initiated from multiple promoters. Promoter-specific expression is regulated by DNA methylation, which is often dysregulated in cancer. Here
Shuo Chen et al.
Cell reports, 32(6), 108007-108007 (2020-08-14)
Stem cell niches provide a microenvironment to support the self-renewal and multi-lineage differentiation of stem cells. Cell-cell interactions within the niche are essential for maintaining tissue homeostasis. However, the niche cells supporting mesenchymal stem cells (MSCs) are largely unknown. Using
Articles
Insulin-like Growth Factors (IGF)
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