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CHOK1

SAFC

CHOZN® CHO K1 Host Cell Line

Suspension-adapted in CD media

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About This Item

UNSPSC Code:
12352200

description

CHOK1 cell line derived from ECACC CHO K1

Quality Level

200

shipped in

dry ice

storage temp.

−196°C

Related Categories

General description

A subclone of the parental CHO cell line, which was derived from the ovary of an adult Chinese hamster. Cells require proline due to the absence of the gene for proline synthesis, the block in the biosynthetic chain lies in the step converting glutamic acid to glutamine γ serialdehyde. They undergo morphological changes in response to cholera toxin.
CHO-K1 cells derived from ECACC CHO K1 and adapted to suspension and serum-free, chemically defined media. Cells are cGMP banked in chemically defined, animal component-free EX-CELL® CD CHO Fusion medium.

Cell Line Origin

Hamster Chinese ovary. The parental CHO-K1 cell line was originated by Puck in 1957.

Physical form

CHOZN CHO K1 cells are provided to customers in vials containing 1 mL at 107 cells/mL. Cells are banked in EX-CELL CD Fusion medium containing 4mM L glutamine and 7% DMSO.

Legal Information

The CHOZN CHO K1 cell line is sold for research use only. For use of this cell line in a commercial process, a commercial license must be taken.
CHOZN is a registered trademark of Merck KGaA, Darmstadt, Germany
EX-CELL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mena Abdelsayed et al.
The Journal of physiology, 593(18), 4201-4223 (2015-07-02)
Cardiac arrhythmias are often associated with mutations in SCN5A the gene that encodes the cardiac paralogue of the voltage-gated sodium channel, NaV 1.5. The NaV 1.5 mutants R1193Q and E1784K give rise to both long QT and Brugada syndromes. Various
T M Trask et al.
The Journal of biological chemistry, 275(32), 24400-24406 (2000-05-29)
Alignment of tropoelastin molecules during the process of elastogenesis is thought to require fibrillin-containing microfibrils. In this study, we have demonstrated that amino-terminal domains of two microfibrillar proteins, fibrillin-1 and fibrillin-2, interact with tropoelastin in solid phase binding assays. The
C Peters et al.
Scientific reports, 6, 31879-31879 (2016-09-02)
Dravet syndrome is the prototype of SCN1A-mutation associated epilepsies. It is characterised by prolonged seizures, typically provoked by fever. We describe the evaluation of an SCN1A mutation in a child with early-onset temperature-sensitive seizures. The patient carries a heterozygous missense
Clara Stead et al.
Journal of biomolecular screening, 21(10), 1042-1053 (2016-07-15)
Glycine receptor 3 (GlyRα3) is a ligand-gated ion channel of the cys-loop family that plays a key role in mediating inhibitory neurotransmission and regulation of pain signaling in the dorsal horn. Potentiation of GlyRα3 function is therefore of interest as
Nouran Abualsaud et al.
Frontiers in cell and developmental biology, 8, 627090-627090 (2021-03-09)
Neuropeptide Y (NPY) has been implicated in the regulation of cellular motility under various physiological and pathological conditions, including cancer dissemination. Yet, the exact signaling pathways leading to these effects remain unknown. In a pediatric malignancy, neuroblastoma (NB), high NPY
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