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74777

Millipore

Astragaloside IV

>98.0%

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About This Item

Empirical Formula (Hill Notation):
C41H68O14
CAS Number:
84687-43-4
Molecular Weight:
784.97
MDL number:
MFCD16036240
UNSPSC Code:
41106200
PubChem Substance ID:
329765850
NACRES:
NA.85

Quality Level

100

Assay

≥98.0% (TLC)
>98.0%

form

powder

mp

295-296 °C (lit.)

SMILES string

CC(C)(O)[C@@H]1CC[C@@](C)(O1)[C@H]2[C@@H](O)C[C@@]3(C)[C@@H]4C[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@H]6C(C)(C)[C@H](CC[C@@]67C[C@@]47CC[C@]23C)O[C@@H]8OC[C@@H](O)[C@H](O)[C@H]8O

InChI

1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1

InChI key

QMNWISYXSJWHRY-YLNUDOOFSA-N

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Biochem/physiol Actions

Anti-inflammatory.

Other Notes

Chemical constituent of Astragali radix

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCB3090
BCCB2207
BCBX5957
BCBS9602V
BCBR2507V

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Li-feng Huang et al.
Fitoterapia, 83(8), 1514-1522 (2012-09-18)
High mobility group box 1 protein (HMGB1), a potent pro-inflammatory cytokine, contributes to the pathogenesis of diverse inflammatory and infectious disorders. Some studies have illustrated the potential effect of HMGB1 on regulatory T cells (Tregs). Astragaloside IV (AST IV) isolated
Dingkun Gui et al.
PloS one, 7(6), e39824-e39824 (2012-06-30)
Glucose-induced reactive oxygen species (ROS) production initiates podocyte apoptosis, which represents a novel early mechanism leading to diabetic nephropathy (DN). Here, we tested the hypothesis that Astragaloside IV(AS-IV) exerts antioxidant and antiapoptotic effects on podocytes under diabetic conditions. Apoptosis, albuminuria
Wenya Shan et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(1), 85-88 (2012-06-30)
To provide a scientific basis for the drug-combination and aim to examine whether astragaloside IV has the impact on the cytochrome P450 enzymes. Tolbutamide, chlorzoxazone, coumarin, nifedipine, and phenacetin were as probe substrates of rat CYP2C9, CYP2E1, CYP2A6, CYP3A4, and
Ming Hao et al.
Zhonghua yi xue za zhi, 92(30), 2104-2107 (2012-11-20)
To explore the protective effects of astragaloside IV on retinal ganglion cells (RGC) incubated under high glucose. Cultured RGC-5 were divided into 3 groups: control, high glucose and high glucose+astragaloside IV. The survival rate of cell was measured by CCK-8
I. Kitagawa et al.
Chemical & Pharmaceutical Bulletin, 31, 698-698 (1983)
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