NE1019
Anti-Myelin Basic Protein Mouse mAb (SMI-99)
liquid, clone SMI-99, Calbiochem®
Synonym(s):
Myelin basic protein antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.43
Recommended Products
biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
SMI-99, monoclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
guinea pig (weakly), mammals
should not react with
chicken, porcine
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
isotype
IgG2b
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MBP(4155)
General description
Purified mouse monoclonal antibody. Recognizes the ~21 kDa myelin basic protein (MBP).
Recognizes the ~21 kDa myelin basic protein in rat brain tissue. Does not recognize the 14 kDa form. Recognizes most mammalian species.
This Anti-Myelin Basic Protein Mouse mAb (SMI-99) is validated for use in ELISA, Immunoblotting, Immunocytochemistry, Frozen Sections, Paraffin Sections for the detection of Myelin Basic Protein.
Immunogen
Epitope: Within amino acids 131-136
human myelin basic protein
Application
ELISA (1:1000)
Immunoblotting (1:1000)
Immunocytochemistry (1:1000)
Frozen Sections (1:1000)
Paraffin Sections (1:1000)
Warning
Toxicity: Standard Handling (A)
Other Notes
Evers, P. and Uylings, H.B. 1997. J. Neurosci. Methods72, 197.
Shin, R.W., et al. 1991. Lab. Invest.64, 693.
Shin, R.W., et al. 1991. Lab. Invest.64, 693.
Recognizes MBP from most mammalian species. Does not recognize the ~14 kDa form of MBP. Detects developing and adult myelin and developing oligodendrocytes. Also distinguishes oligodendrocytes from astrocytes, microglia, neurons, and other cells in brain tissue sections. In combination with Anti-Myelin Basic Protein Mouse mAb (SMI-91) (Cat. No. NE1020) and/or Anti-Myelin Basic Protein Mouse mAb (SMI-94) (Cat. No. NE1018) this antibody is useful for immunocytochemical studies on the progression of normal and pathologic myelination. Antibody should be titrated for optimal results in individual systems.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Jane L Zhu et al.
Journal of translational medicine, 20(1), 41-41 (2022-01-26)
Morphea is an autoimmune, sclerosing skin disorder. Despite the recent emphasis on immune dysregulation in morphea, the role of autoantibodies in morphea pathogenesis or utility as biomarkers are poorly defined. Autoantigen microarray was used to profile autoantibodies from the serum
Michela Losurdo et al.
Brain sciences, 10(4) (2020-04-16)
Traumatic brain injury (TBI) commonly results in primary diffuse axonal injury (DAI) and associated secondary injuries that evolve through a cascade of pathological mechanisms. We aim at assessing how myelin and oligodendrocytes react to head angular-acceleration-induced TBI in a previously
Gerben van Hameren et al.
Acta neuropathologica communications, 7(1), 86-86 (2019-06-13)
Mitochondria are critical for the function and maintenance of myelinated axons notably through Adenosine triphosphate (ATP) production. A direct by-product of this ATP production is reactive oxygen species (ROS), which are highly deleterious for neurons. While ATP shortage and ROS
L N Collins et al.
The Journal of comparative neurology, 526(11), 1843-1858 (2018-04-18)
Both the lateral olfactory tract (LOT) and anterior limb of the anterior commissure (AC) carry olfactory information. The LOT forms the projection from the olfactory bulb to the ipsilateral olfactory cortices, while the AC carries odor information across the midline
Di Xie et al.
Journal of neuroinflammation, 17(1), 57-57 (2020-02-18)
Microglia activation is associated with the development of hypoxic-ischemic brain injury (HIBI). Neuroinflammation suppression might be a suitable therapeutic target in hypoxic oligodendrocyte injury. This study aims to determine whether clemastine can improve hypomyelination by suppressing the activated microglia and
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