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05-446

Sigma-Aldrich

Anti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4

clone A16/17, Upstate®, from mouse

Synonym(s):

p75 Low Affinity Neurotrophin Receptor, NGFR

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

A16/17, monoclonal

species reactivity

monkey, human

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
neutralization: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_002507

UniProt accession no.

P08138

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... NGFR(4804)

Specificity

low affinity p75NTR

Immunogen

Human melanoma cell line WM245.

Application

Anti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4 detects level of p75NTR (Neurotrophin Receptor) & has been published & validated for use in IP, WB, IH, NEUT.
Research Category
Neuroscience
Research Sub Category
Kinases & Phosphatases

Neurodegenerative Diseases

Quality

routinely evaluated by immunoblot on RIPA lysates from HS294T cells

Target description

69kDa

Linkage

Replaces: 04-1111

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein G Chromatography

Storage and Stability

2 years at -20°C

Other Notes

Due to license agreement restrictions, this product cannot be purchased for resale.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Immuno-electron microscopy characterization of human bone marrow stromal cells with anti-NGFR antibodies.
Caneva, L, et al.
Blood Cells, Molecules and Diseases, 21, 73-85 (1995)
C Dominici et al.
Journal of neuro-oncology, 31(1-2), 57-64 (1997-01-01)
In neuroblastoma, high levels of mRNA for p140trkA and p75LNGFR neurotrophin receptors are predictive of favorable outcome. Their evaluation by Northern blot, however, requires substantial amounts of tissue and this prevents their routine evaluation as well as the possibility for
Low-affinity nerve growth factor receptor immunoreactivity in the human urinary bladder.
Wakabayashi, Y, et al.
Neuroscience Letters, 186, 9-12 (1995)
S M Mooney et al.
Neuroscience, 149(2), 372-381 (2007-09-18)
Organotypic cultures of rat cortex were used to test the hypotheses that nerve growth factor (NGF) is neuroprotective for immature cortical neurons and that ethanol abolishes this neuroprotection in a developmental stage-dependent manner. Samples were obtained on gestational day (G)
J Du et al.
The Journal of cell biology, 150(6), 1423-1434 (2000-09-20)
Brain-derived neurotrophic factor (BDNF) has been shown to regulate neuronal survival and synaptic plasticity in the central nervous system (CNS) in an activity-dependent manner, but the underlying mechanisms remain unclear. Here we report that the number of BDNF receptor TrkB
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