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858122P

Avanti

16:0 Lyso PG

1-palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt), powder

Synonym(s):

1-hexadecanoyl-sn-glycero-3-phospho-(1′racglycerol) (sodium salt); PG(16:0/0:0); 110711

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About This Item

Empirical Formula (Hill Notation):
C22H44O9PNa
CAS Number:
326495-22-1
Molecular Weight:
506.54
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (LPG; may contain up to 10% of the 2-LPG isomer, TLC)

form

powder

packaging

pkg of 1 × 1 g (858122P-1g)
pkg of 1 × 500 mg (858122P-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 858122P

shipped in

dry ice

storage temp.

−20°C

General description

1-palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1′-rac-glycerol) or LPG is a 16 carbon lipid with a phosphate headgroup and hydrocarbon tail. It is negatively charged and has a critical micelle concentration of 0.6 mM.

Application

16:0 Lyso PG has been used in the synthesis of acetonide-protected pyrene PG. It may be used for the elution of cytochrome b558 in ion exchange column purification. It may also be used for the solubilisation of eubacterium proton pump protein.

Biochem/physiol Actions

1-palmitoyl-2-hydroxy-sn-glycero-3-phospho-(1′-rac-glycerol) is often used in solubilization and purification of transmembrane proteins. It has been used in the melanosomal protein, Pmel17 aggregation studies.

Packaging

20 mL Clear Glass Screw Cap Vial (858122P-1g)
20 mL Clear Glass Screw Cap Vial (858122P-500mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lysophospholipids induce fibrillation of the repeat domain of Pmel17 through intermediate core-shell structures
Pedersen JN, et al.
Biochimica et biophysica acta. Proteins and proteomics, 1867(5), 519-528 (2019)
Lipases and Phospholipases, 149-158 (2012)
Lysophosphatidylglycerol: a novel effective detergent for solubilizing and purifying the cystic fibrosis transmembrane conductance regulator
Huang P, et al.
Analytical Biochemistry, 259(1), 89-97 (1998)
Aspartate-histidine interaction in the retinal schiff base counterion of the light-driven proton pump of Exiguobacterium sibiricum
Balashov SP, et al
Biochemistry, 51(29), 5748-5762 (2012)
P Huang et al.
Analytical biochemistry, 259(1), 89-97 (1998-05-30)
Similar to the recombinant cystic fibrosis transmembrane conductance regulator (CFTR) expressed in Sf9 insect cells, underglycosylated CFTR expressed in yeast is not effectively solubilized by a variety of commonly used detergents, requiring instead harsh alkali and SDS treatments, which would
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