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840026C

Avanti

Liver PE

Avanti Research™ - A Croda Brand 840026C

Synonym(s):

L-α-phosphatidylethanolamine (Liver, Bovine)

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About This Item

CAS Number:
383907-31-1
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (840026C-25mg)
pkg of 5 × 4 mL (840026C-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840026C

concentration

10 mg/mL (840026C-25mg)
25 mg/mL (840026C-500mg)

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O

InChI

1S/C43H78NO8P/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-43(46)52-41(40-51-53(47,48)50-38-37-44)39-49-42(45)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2/h11,13,17,19,22,24,28,30,41H,3-10,12,14-16,18,20-21,23,25-27,29,31-40,44H2,1-2H3,(H,47,48)/b13-11-,19-17-,24-22-,30-28-/t41-/m1/s1

InChI key

ANRKEHNWXKCXDB-BHFWLYLHSA-N

General description

Phosphatidylethanolamine (PE) consists of a small polar head group with fatty acid chains. It is the second most plenteous glycerophospholipid in eukaryotic cells. PE is a non-bilayer forming phospholipid. It is found abundantly in the mitochondria.

Application

Liver PE is suitable for the preparation of liposomes.

Biochem/physiol Actions

Phosphatidylethanolamine (PE) is involved in providing rigidity to the cell membrane via hexagonal phase structures, which promote tight packing of the membrane bilayer formed by phosphotidylcholine. It is also involved in the conversion of prions from the non-toxic to toxic conformation. PE also initiates the autophagosome formation by attaching covalently to the autophagy Atg8 protein.

Packaging

5 mL Clear Glass Sealed Ampule (840026C-25mg)
5 mL Clear Glass Sealed Ampule (840026C-500mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Target Organs

Liver,Kidney, Respiratory system

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A novel flow cytometric assay to quantify interactions between proteins and membrane lipids
Temmerman K and Nickel W
Journal of Lipid Research, 50(6), 1245-1254 (2009)
Phosphatidylethanolamine metabolism in health and disease
International Review of Cell and Molecular Biology, 321, 29-88 (2016)
Nadezhda Y Davydova et al.
The Biochemical journal, 476(23), 3661-3685 (2019-11-22)
In this study, we investigate the ability of ethanol-inducible CYP2E1 to interact with other cytochrome P450 species and affect the metabolism of their substrates. As a model system, we used CYP2E1-enriched human liver microsomes (HLM) obtained by the incorporation of
Ethanolamine and Phosphatidylethanolamine Partners in Health and Disease
Patel D and Witt SN
Oxidative Medicine and Cellular Longevity, 2017, 29-88 (2017)
Koen Temmerman et al.
Journal of lipid research, 50(6), 1245-1254 (2009-01-16)
A diverse set of experimental systems has been developed to probe protein-lipid interactions. These include measurements with the headgroups of membrane lipids in solution, immobilized membrane lipids, and analysis of protein binding to membrane lipids reconstituted in liposomes. Each of

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