922668
Dichloromeldrum′s acid
≥95%
Synonym(s):
5,5-Dichloro-2,2-dimethyl-1,3-dioxane-4,6-dione, DiCMA, Lennox-Heard chloroacetylation reagent
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About This Item
Empirical Formula (Hill Notation):
C6H6Cl2O4
CAS Number:
Molecular Weight:
213.02
UNSPSC Code:
12352106
NACRES:
NA.22
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Application
Lennox-Heard reagent (also known as dichloromeldrum′s acid, or DiCMA) is a stable, shelf-stable reagent for the conversion of alkyl and aryl amines to dichloroacetamides. This reagent is atom economical and the byproducts of acetone and CO2 are easily removed, and provides a greener, practical method of installing these medicinally relevant motifs onto a variety of compounds in high yield.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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David M Heard et al.
Organic letters, 23(9), 3368-3372 (2021-04-13)
Dichloromeldrum's acid is introduced as a bench-stable, nonvolatile reagent for the dichloroacetylation of anilines and alkyl amines to produce α,α-dichloroacetamides, which are important motifs for medicinal chemistry. Products are formed in good to excellent yields with reagent grade solvents, and
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