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377104

Sigma-Aldrich

1-Acetylindole

98%

Synonym(s):

NSC 521758

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About This Item

Empirical Formula (Hill Notation):
C10H9NO
CAS Number:
576-15-8
Molecular Weight:
159.18
EC Number:
209-396-1
MDL number:
MFCD00038005
UNSPSC Code:
12352100
PubChem Substance ID:
24863492
NACRES:
NA.22

Assay

98%

form

liquid

refractive index

n20/D 1.607 (lit.)

bp

123-125 °C/8 mmHg (lit.)

density

1.387 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CC(=O)n1ccc2ccccc12

InChI

1S/C10H9NO/c1-8(12)11-7-6-9-4-2-3-5-10(9)11/h2-7H,1H3

InChI key

UUCUQJHYUPXDHN-UHFFFAOYSA-N

General description

Quantum chemical calculations of ground state energy, geometrical structure and vibrational wavenumbers of 1-acetylindole has been carried out using density functional (DFT/B3LYP) method. Regioselective acylations of 1-acetylindole (N-acetylindole) under Friedel-Crafts reaction has been reported. Reaction of 1-acetylindole with manganese(III) acetate in the presence of malonic acid, is reported to afford 4-acetyl-3,3a,4,8b-tetrahydro-2H-furo[3,2-b]indol-2-one.

Application

1-Acetylindole may be used in the stereocontrolled synthesis of (±)-geissoschizine. It may be used in the preparation of (1-acetyl-κO-indolyl-κC2)tetracarbonylmanganese, via a standard cyclomanganation procedure.
Reactant for preparation of:
  • Antimycobacterial agents
  • Cyclin-dependent kinase (CDK2) inhibitors

Reactant for:
  • C3-C3 oxidative cross-coupling reactions

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A concise, stereoselective synthesis of (?)-geissoschizine.
Bennasar M, et al.
Tetrahedron Letters, 37(50), 9105-9106 (1996)
Regioselective acylations at the 2 and 6 position of N-acetylindole.
Cruz R, et al.
Tetrahedron Letters, 42(8), 1467-1469 (2001)
Vikas K Shukla et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 133, 626-638 (2014-07-06)
Quantum chemical calculations of ground state energy, geometrical structure and vibrational wavenumbers of 1-acetylindole were carried out using density functional (DFT/B3LYP) method with 6-311++G(d,p) basis set. The FT-IR and FT-Raman spectra were recorded in the condensed state. The fundamental vibrational
Mangenese (III) acetate oxidation of 1-acetylindole derivatives.
Izumi T, et al.
Journal of Heterocyclic Chemistry, 30(4), 1133-1136 (1993)
Synthesis and alkyne-coupling chemistry of cyclomanganated 1-and 3-acetylindoles, 3-formylindole and analogues.
Depree GJ, et al.
Journal of Organometallic Chemistry, 691(4), 667-679 (2006)

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