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SML0909

Sigma-Aldrich

Nefopam hydrochloride

≥98% (HPLC)

Synonym(s):

3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride, 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H19NO · HCl
CAS Number:
23327-57-3
Molecular Weight:
289.80
EC Number:
245-585-5
MDL number:
MFCD00012750
UNSPSC Code:
12352200
PubChem Substance ID:
329825616
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

mp

260 °C (dec.) (lit.)

solubility

H2O: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

Cl.CN1CCOC(c2ccccc2)c3ccccc3C1

InChI

1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H

InChI key

CNNVSINJDJNHQK-UHFFFAOYSA-N

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Application

Nefopam hydrochloride has been used as a standard for the quantitative determination of tramadol by gas chromatography–mass spectrometry (GC/MS).

Biochem/physiol Actions

Nefopam is a centrally-acting analgesic drug of the benzoxazocine chemical class. Nefopam is a non-opioid, but has a potentiating effect on morphine and other opioids. Its mechanism of action is not certain, but may involve its action as a dopamine/serotonin/norepinephrine reuptake inhibitor.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301 + H311 + H331

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yoshie Taniguchi et al.
Anesthesia and analgesia, 111(2), 409-414 (2010-06-10)
Mild hypothermia has been shown to improve neurologic outcome after cardiac arrest. Nefopam, a centrally acting, nonsedative analgesic, decreases the threshold of shivering, but not vasoconstriction, and thus might be a suitable drug for induction of therapeutic hypothermia. However, not
O Mialon et al.
Journal de gynecologie, obstetrique et biologie de la reproduction, 40(2), 137-143 (2010-10-12)
Analgesic protocols administered before a follicular puncture under local anesthesia are well tolerated when using NSAIDs, but we still do not know their possible impacts on in vitro fertilization (IVF) outcomes. A retrospective monocentric study using two consecutive temporal cohorts
A C Van Elstraete et al.
Minerva anestesiologica, 79(3), 232-239 (2012-12-18)
The analgesic efficacy of nefopam and of paracetamol has been shown in the postoperative period after mild- and moderate-pain surgery. The aim of this study was to define the median effective analgesic doses of each drug and of their combination
Raymond Poon et al.
PloS one, 7(5), e37940-e37940 (2012-06-06)
Fibroproliferative disorders include neoplastic and reactive processes (e.g. desmoid tumor and hypertrophic scars). They are characterized by activation of β-catenin signaling, and effective pharmacologic approaches are lacking. Here we undertook a high throughput screen using human desmoid tumor cell cultures
Bethan L Richards et al.
The Journal of rheumatology. Supplement, 90, 28-33 (2012-09-04)
To determine the efficacy and safety of neuromodulators for pain management in patients with inflammatory arthritis. A Cochrane systematic review was performed as part of the 3e Initiative on pain management in inflammatory arthritis. We searched Medline, Embase, and Cochrane
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