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R7017

Sigma-Aldrich

Resazurin sodium salt

powder, BioReagent

Synonym(s):

7-Hydroxy-3H-phenoxazin-3-one-10-oxide sodium salt

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About This Item

Empirical Formula (Hill Notation):
C12H6NNaO4
CAS Number:
62758-13-8
Molecular Weight:
251.17
Beilstein:
3794971
EC Number:
263-718-5
MDL number:
MFCD00005036
UNSPSC Code:
12352207
PubChem Substance ID:
24899387
NACRES:
NA.75

product line

BioReagent

form

powder

composition

Dye content, ~80%

pH

3.8-6.5, orange to violet

solubility

H2O: soluble

λmax

600 nm

SMILES string

[Na+].[O-]c1ccc2c(OC3=CC(=O)C=CC3=[N+]2[O-])c1

InChI

1S/C12H7NO4.Na/c14-7-1-3-9-11(5-7)17-12-6-8(15)2-4-10(12)13(9)16;/h1-6,14H;/q;+1/p-1

InChI key

IVGPGQSSDLDOLH-UHFFFAOYSA-M

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Application

Resazurin sodium salt has been used in viability assay:
  • to measure cell viability of A. fumigatus
  • to assess cell proliferation
  • to determine A. fumigatus viability in high-throughput screenings of microbial natural extracts

For the measurement of metabolic activity and proliferation of living cells. The bioreduction of the dye reduces the amount of the oxidized form (blue) and concomitantly increases the fluorescent intermediate (red).

Biochem/physiol Actions

Resazurin is a blue, non-fluorescent dye originally used to test milk/biological fluids for bacterial and yeast contamination. It is also useful in sperm viability and semen quality test. Resazurin is applicable in cytotoxicity determination.

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Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin
Monteiro MC, et al.
Journal of Biomolecular Screening, 17(4), 542-549 (2012)
Human umbilical cord tissue-derived mesenchymal stromal cells attenuate remodeling after myocardial infarction by proangiogenic, antiapoptotic, and endogenous cell-activation mechanisms
Nascimento DS, et al.
Stem Cell Research & Therapy, 5(1), 5-5 (2012)
Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010)
Valiante V, et al.
Antimicrobial agents and chemotherapy, 59(9), 5145-5153 (2015)
Sugandha Bhatia et al.
Journal of clinical medicine, 8(6) (2019-06-27)
Dynamic interconversions between transitional epithelial and mesenchymal states underpin the epithelial mesenchymal plasticity (EMP) seen in some carcinoma cell systems. We have delineated epithelial and mesenchymal subpopulations existing within the PMC42-LA breast cancer cell line by their EpCAM expression. These
Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
O Brien J, et al.
European Journal of Biochemistry, 267(17), 5421-5426 (2000)
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