M6316

MRS 1754 hydrate

≥98% (HPLC), solid

• Synonym(s): 8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
• Empirical Formula (Hill Notation): C₂₆H₂₆N₆O₄ · xH₂O
• CAS Number: 264622-58-4
• Molecular Weight: 486.52 (anhydrous basis)
• MDL number: MFCD11046004
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278793
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: solid
• color: off-white
• solubility: DMSO: soluble >10 mg/mL
• storage temp.: room temp
• SMILES string: O.CCCN1C(=O)N(CCC)c2[nH]c(nc2C1=O)-c3ccc(OCC(=O)Nc4ccc(cc4)C#N)cc3
• InChI: 1S/C26H26N6O4.H2O/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19;/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30);1H2
• InChI key: ZACJDWOPQROWIK-UHFFFAOYSA-N
• Gene Information: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) ; rat ... Adora1(29290) , Adora2a(25369) , Adora2b(29316)

Description

Application

MRS 1754 hydrate has been used as an adenosine receptor A2B (RA2B) antagonist:

• to study its effects on endothelial nitric oxide synthase (eNOS) phosphorylation induced by short-term acetate stimulation in human umbilical vein endothelial cells (HUVECs)
• blastema formation in zebrafish
• to serve as a positive control in the anti-sickling assay and to study the role of RA2B in the same

Biochem/physiol Actions

MRS 1754 hydrate is a p-cyanoanilide xanthine derivative. It might act as a potential anti-asthmatic drug.

MRS 1754 hydrate is a potent A_2B adenosine receptor antagonist.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold under license from Adenosine Therapeutics LLC.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves