L6512
Lectin from Helix pomatia
biotin conjugate, lyophilized powder
Synonym(s):
Helix pomatia agglutinin, HPA
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
conjugate
biotin conjugate
form
lyophilized powder
extent of labeling
2-4 mol biotin per mol protein
impurities
salt, free
storage temp.
−20°C
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General description
Lectins are carbohydrate-binding proteins, omnipresent, found in fungi, plants and animals. These oligomeric proteins are characterized by the presence of a carbohydrate recognition domain.
Application
Lectin from Helix pomatia has been used to study its binding activities in Gyrodactylus derjavini parasitizing fins of Oncorhynchus mykiss.
Biochem/physiol Actions
Lectin is useful in glycoconjugate characterizing, imaging and targeting. Lectin participates in host recognition and tissue adhesion. Lectins shows resistance to proteolytic degradation in vivo.
HPA has anti-A human blood group specificity and has an affinity for terminal N-acetyl-α-D-galactosaminyl residues. Conjugates are prepared from affinity purified lectin.
Analysis Note
Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, of a 1 mg/ml solution. This activity is the lowest concentration to agglutinate a 2% suspension of human blood group A erythrocytes after 1 hour incubation at 25 °C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Overview of fish immunity
Mucosal Health in Aquaculture, 3-54 (2015)
Cédric Jäger et al.
BMC nephrology, 23(1), 178-178 (2022-05-11)
Recurrence of IgA nephropathy (IgAN) after kidney transplantation occurs in about 30% of patients. The relevance of recurrence for the long-term graft survival is expected to increase, since graft survival continues to improve. In a nested study within the Swiss
Histochemical characteristics of Gyrodactylus derjavini parasitizing the fins of rainbow trout (Oncorhynchus mykiss)
Buchmann K, et al.
Folia Parasitol (Praha), 45(4), 312-318 (1998)
PEAS AND LENTILS
Encyclopedia of food sciences and nutrition, 4433-4440 (2003)
Yasuyuki Matsumoto et al.
Science advances, 8(43), eabm8783-eabm8783 (2022-10-29)
The underlying pathology of immunoglobulin A (IgA) nephropathy (IgAN), the most common glomerulonephritis worldwide, is driven by the deposition of immune complexes containing galactose-deficient IgA1 [Tn(+)IgA1] in the glomerular mesangium. Here, we report that novel anti-Tn circulating immune complexes (anti-Tn
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