K3750

L-Kynurenine sulfate salt

≥98% (HPLC), suitable for ligand binding assays

• Synonym(s): β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
• Linear Formula: C₁₀H₁₂N₂O₃ · H₂SO₄
• CAS Number: 16055-80-4
• Molecular Weight: 306.29
• MDL number: MFCD00039104
• UNSPSC Code: 12352209
• PubChem Substance ID: 24896233
• NACRES: NA.26

Properties

• product name: L-Kynurenine sulfate salt, crystalline
• Assay: ≥98% (HPLC)
• form: crystalline
• technique(s): ligand binding assay: suitable
• color: light yellow
• storage temp.: −20°C
• SMILES string: OS(O)(=O)=O.N[C@@H](CC(=O)c1ccccc1N)C(O)=O
• InChI: 1S/C10H12N2O3.H2O4S/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15;1-5(2,3)4/h1-4,8H,5,11-12H2,(H,14,15);(H2,1,2,3,4)/t8-;/m0./s1
• InChI key: KAXRWMOLNJZCEW-QRPNPIFTSA-N

Description

Application

L-Kynurenine sulfate salt has been used as a substrate to study the enzyme activity of kynurenine aminotransferase. It has also been used in the synthesis of Kyn adducts of certain amino acids .

Biochem/physiol Actions

L-Kynurenine (L-Kyn) is a precursor of kynurenic acid which is the only recognized endogenous excitatory amino acid receptor antagonist in the central nervous system. L-Kyn is known to be a pigment generating component in animals. In mammals, it modulates the transmission of glutamate neurotransmitter. It is also considered to be a sex-attracting pheromone in vertebrates.

L-Kynurenine is a key intermediate in the breakdown of L-tryptophan and the formation of nicotinamide adenine dinucleotide (NAD+) via the kynurenine pathway. L-kynurenine is involved in a variety of neurological processes and diseases. L-kynurenine is a substrate for kynureninase/kynurenine hydrolase; kynurenine 3-monooxygenase and kynurenine-oxoglutarate transaminase.

Key intermediate in the breakdown pathway of tryptophan.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves