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K113

Sigma-Aldrich

Ketamine hydrochloride/xylazine hydrochloride solution

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About This Item

CAS Number:
61763-23-3
MDL number:
MFCD00798875
UNSPSC Code:
12352116
PubChem Substance ID:
329817124
NACRES:
NA.77

form

solution

Quality Level

200

drug control

USDEA Schedule III; stupéfiant (France); regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain)

color

colorless

storage temp.

2-8°C

SMILES string

Cl.Cl.Cc1cccc(C)c1NC2=NCCCS2.CNC3(CCCCC3=O)c4ccccc4Cl

InChI

1S/C13H16ClNO.C12H16N2S.2ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;;/h2-3,6-7,15H,4-5,8-9H2,1H3;3,5-6H,4,7-8H2,1-2H3,(H,13,14);2*1H

InChI key

IYJHJWJNWIPQFJ-UHFFFAOYSA-N

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Biochem/physiol Actions

This is a solution of ketamine hydrochloride, an NMDA receptor antagonist, and xylazine hydrochloride, an α2- adrenergic receptor agonist.

Other Notes

Telephone orders are not accepted for this product.

Kit Components Only

Product No.
Description
  • Ketamine hydrochloride 80 mg/mL
  • Xylazine hydrochloride 12 mg/mL

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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I Soltesz et al.
Journal of neurophysiology, 70(1), 97-116 (1993-07-01)
1. Intracellularly recorded low- and high-frequency (4-6 and 25-50 Hz, respectively), rhythmic, spontaneous membrane potential oscillations were investigated in pyramidal neurons of the rat hippocampus in vivo, during theta (theta, 4-6 Hz) electroencephalographic (EEG) activity, under ketamine-xylazine anesthesia. 2. The
Azim Ullah Shamsul Islam et al.
Molecules (Basel, Switzerland), 25(19) (2020-10-04)
Physiological Glucocorticoids are important regulators of the immune system. Pharmacological GCs are in widespread use to treat inflammatory diseases. Adrenalectomy (ADX) has been shown to exacerbate renal injury through inflammation and oxidative stress that results in renal impairment due to
Ehsan Saboory et al.
Experimental physiology, 105(5), 783-792 (2020-02-14)
What is the central question of this study? Do changes in levels of angiogenesis-related mediators [vascular endothelial growth factor-A (VEGF-A), thrombospondin-1 (TSP-1) and nuclear factor-κB (NF-κB)] in the sciatic nerve mediate diabetic neuropathy in the streptozotocin-induced type 1 diabetic male rat?
J P Gratton et al.
British journal of pharmacology, 114(3), 720-726 (1995-02-01)
1. In the present study, the precursors of endothelin-1, endothelin-2 and endothelin-3 were tested for their pressor and bronchoconstrictor properties in the anaesthetized guinea-pig. In addition, the effects of big-endothelin-1 and endothelin-1 were assessed under urethane or ketamine/xylazine anaesthesia. 2.
J M Tepper et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 15(4), 3092-3103 (1995-04-01)
Evidence from electrophysiological studies has suggested an inhibitory interaction between GABAergic neurons in substantia nigra pars reticulata and dopaminergic neurons in pars compacta. However, that this inhibitory interaction is due to a projection from pars reticulata to pars compacta has
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Chromatograms

application for HPLC

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