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I6658

Sigma-Aldrich

Isradipine

≥98% (HPLC), solid

Synonym(s):

4-(4-Benzofurazanyl)-1,-4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester

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About This Item

Empirical Formula (Hill Notation):
C19H21N3O5
CAS Number:
75695-93-1
Molecular Weight:
371.39
MDL number:
MFCD00153820
UNSPSC Code:
12352200
PubChem Substance ID:
24724517
NACRES:
NA.77

description

Store under nitrogen

Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: >10 mg/mL

originator

Novartis

storage temp.

2-8°C

SMILES string

COC(=O)C1=C(C)NC(C)=C(C1c2cccc3nonc23)C(=O)OC(C)C

InChI

1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3

InChI key

HMJIYCCIJYRONP-UHFFFAOYSA-N

Gene Information

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , CACNA2D1(781)

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Application

Isradipine has been used to explore neuroprotective activity.

Biochem/physiol Actions

Isradipine is considered as an active calcium channel blocker, used to treat hypertension.
L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
079K4708V
079K47081
079K4708
038K46182
038K46181

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Fernando A Aguiar et al.
Electrophoresis, 32(19), 2673-2682 (2011-10-11)
A simple enantioselective method based on CE using CD as chiral selector was developed and validated for the determination of isradipine (IRD) enantiomers in a pharmaceutical formulation and for the determination of IRD enantiomers in degradation studies. After optimization, the
Vincent Malaterre et al.
International journal of pharmaceutics, 376(1-2), 56-62 (2009-04-23)
Despite more than 30 years of clinical use, only few studies have been published reporting on the release mechanism underlying the drug delivery from push-pull osmotic pumps (PPOP). The aim of this study is to understand which factors have an
Tanya Simuni et al.
Movement disorders : official journal of the Movement Disorder Society, 25(16), 2863-2866 (2010-09-08)
Recent data suggests that isradipine, a dihydropyridine calcium channel blocker, is neuroprotective in preclinical models of parkinsonism. Isradipine has not been systematically studied in patients with Parkinson's disease (PD). The aim of this study was to evaluate safety and tolerability
Invasomes of isradipine for enhanced transdermal delivery against hypertension: formulation, characterization, and in vivo pharmacodynamic study
Qadri G R, et al.
Artificial Cells, Nanomedicine, and Biotechnology (Print), 45(1), 139-145 (2017)
E Ilijic et al.
Neurobiology of disease, 43(2), 364-371 (2011-04-26)
The motor symptoms of Parkinson's disease (PD) are due to the progressive loss of dopamine (DA) neurons in substantia nigra pars compacta (SNc). Nothing is known to slow the progression of the disease, making the identification of potential neuroprotective agents
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