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40941

Sigma-Aldrich

Methylphosphonic acid

99.0-101.0% (T)

Synonym(s):

MPA

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About This Item

Linear Formula:
CH3P(O)(OH)2
CAS Number:
993-13-5
Molecular Weight:
96.02
Beilstein:
1739372
EC Number:
213-607-2
MDL number:
MFCD00002137
UNSPSC Code:
12352204
PubChem Substance ID:
329756038
NACRES:
NA.25

Quality Level

100

Assay

99.0-101.0% (T)

loss

≤2.0% loss on drying

pH

0.9-1.4

mp

103-109 °C
105-107 °C (lit.)

solubility

H2O: 2.88 g in 30 mL, clear, colorless

cation traces

Al: ≤5 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

UV absorption

λ: 260 nm Amax: ≤0.05
λ: 280 nm Amax: ≤0.04

SMILES string

CP(O)(O)=O

InChI

1S/CH5O3P/c1-5(2,3)4/h1H3,(H2,2,3,4)

InChI key

YACKEPLHDIMKIO-UHFFFAOYSA-N

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Application

Highly pure methylphosphonic acid for phosphoproteome analysis

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H314

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

>392.0 °F - Pensky-Martens closed cup

Flash Point(C)

> 200 °C - Pensky-Martens closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mostafa Zarei et al.
Journal of proteome research, 11(8), 4269-4276 (2012-07-10)
In large-scale phosphoproteomics studies, fractionation by strong cation exchange (SCX) or electrostatic repulsion-hydrophilic interaction chromatography (ERLIC) is commonly used to reduce sample complexity, fractionate phosphopeptides from their unmodified counterparts, and increase the dynamic range for phosphopeptide identification. However, these procedures
Mostafa Zarei et al.
Journal of proteome research, 10(8), 3474-3483 (2011-06-21)
Reversible phosphorylations play a critical role in most biological pathways. Hence, in signaling studies great effort has been put into identification of a maximum number of phosphosites per experiment. Mass spectrometry (MS)-based phosphoproteomics approaches have been proven to be an
C E Pritchard et al.
Nucleic acids research, 22(13), 2592-2600 (1994-07-11)
The HIV-1 regulatory proteins tat and rev are both RNA binding proteins which recognize sequences in duplex RNA which are close to structural distortions. Here we identify phosphate contacts which are critical for each binding reaction by use of a
Stefan Loroch et al.
Analytical chemistry, 87(3), 1596-1604 (2014-11-19)
In the past decade, several strategies for comprehensive phosphoproteome analysis have been introduced. Most of them combine different phosphopeptide enrichment techniques and require starting material in the milligram range, as a consequence of their insufficient sensitivity. This limitation impairs the
H Lindner et al.
Journal of chromatography. A, 782(1), 55-62 (1998-01-24)
A new two-step high-performance liquid chromatography (HPLC) procedure has been developed to separate modified histone H1 subtypes. Reversed-phase (RP) HPLC followed by hydrophilic-interaction liquid chromatography (HILIC) was used for analytical and semi-preparative scale fractionation of multi-phosphorylated H1 histone subtypes into
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