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A1968

Sigma-Aldrich

Ascorbic acid 6-palmitate

meets USP testing specifications

Synonym(s):

6-O-Palmitoyl-L-ascorbic acid, L-Ascorbic acid 6-hexadecanoate, L-Ascorbyl palmitate, Ascorbic acid 6-palmitate, NSC 402451

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About This Item

Empirical Formula (Hill Notation):
C22H38O7
CAS Number:
137-66-6
Molecular Weight:
414.53
Beilstein:
96552
EC Number:
205-305-4
MDL number:
MFCD00005377
UNSPSC Code:
12352205
PubChem Substance ID:
24890608
NACRES:
NA.21

biological source

synthetic

Quality Level

200

Agency

USP/NF
meets USP testing specifications

Assay

95.0-100.5%

form

powder

color

light yellow

application(s)

pharmaceutical (small molecule)

SMILES string

CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O

InChI

1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21+/m0/s1

InChI key

QAQJMLQRFWZOBN-LAUBAEHRSA-N

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General description

Ascorbic acid 6-palmitate/L-Ascorbyl 6-palmitate (AP) is a derivative of a synthetic lipophilic ascorbic acid.

Biochem/physiol Actions

L-Ascorbyl 6-palmitate (AP) is used as preservative in foods. In mice, AP works as a dietary antitumor promoter. 

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000427154
0000427154
0000414474
0000414474
0000349144

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A comparison of L-ascorbic acid and L-ascorbyl 6-palmitate utilization in Guinea Pigs and humans
Johnston CS, et al.
Nutrition Research (New York, N.Y.), 14(10), 1465-1471 (1994)
L Capretto et al.
International journal of pharmaceutics, 440(2), 195-206 (2012-08-14)
The current paper reports the production of polymeric micelles (PMs), based on pluronic block-copolymers, as drug carriers, precisely controlling the cellular delivery of drugs with various physico-chemical characteristics. PMs were produced with a microfluidic platform to exploit further control on
Milagro Mottola et al.
Biochimica et biophysica acta, 1828(11), 2496-2505 (2013-06-29)
Ascorbyl palmitate (ASC16) is an anionic amphiphilic molecule of pharmacological interest due to its antioxidant properties. We found that ASC16 strongly interacted with model membranes. ASC16 penetrated phospholipid monolayers, with a cutoff near the theoretical surface pressure limit. The presence
Rangrong Yoksan et al.
Colloids and surfaces. B, Biointerfaces, 76(1), 292-297 (2009-12-17)
The encapsulation of ascorbyl palmitate (AP) in chitosan particles was carried out by droplet formation via an oil-in-water emulsion, followed by droplet solidification via ionic gelation using sodium triphosphate pentabasic (TPP) as a cross-linking agent. The success of AP encapsulation
Yali Yuan et al.
Analytica chimica acta, 701(2), 169-173 (2011-08-02)
Vitamin C derivatives (VCDs) have been widely used as the alternative and stable sources of vitamin C, and accordingly exhibit many new applications, such as anti-tumor and central nervous system drug delivery. In this study, their Ru(bpy)(3)(2+) electrochemiluminescence (ECL) properties
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