SCT073

BioTracker NIR Amyloid-ß Plaque Imaging Dye

Near-Infrared probe for live cell imaging of amyloid-ß (Aß) plaques, critical for the early detection of Alzheimer′s disease.

• UNSPSC Code: 12352207
• NACRES: NA.21

Properties

• form: lyophilized (dark red)
• technique(s): immunocytochemistry: suitable; immunohistochemistry: suitable
• detection method: fluorometric

Description

General description

Alzheimer′s disease (AD) is a progressive neurodegenerative brain disorder and does not have a proper cure yet. The formation and accumulation of amyloid-ß (Aß) plaques in the brain is thought to be a critical pathological hallmark for early diagnosis of AD. Current gold standard probes for histological staining of amyloid fibrils, such as thioflavin derivatives, have several drawbacks. These probes suffer from noises from always-on pattern, limited blood-brain-barrier (BBB) penetration and distorted signals.BioTracker NIR Amyloid-ß Plaque Imaging Dye is aggregation-induced-emission (AIE) active probe that can be used to detect amyloid-ß plaques in vivo as well as ex-vivo. This probe has been tested in mouse models of AD, as well as ex-vivo brain tissue sections. The BioTracker probe possess excellent features, such as: (1) ultrahigh signal-to-noise (S/N) ratio with integrating background minimization and fidelity signal amplification, (2) remarkable binding affinity to Aß plaques with efficient BBB penetrability, and (3) NIR AIE-active emission with excellent photostability. Spectral Properties:Absorbance: 500 nmEmission: 720 nmResearch Category:Alzheimer′s DiseaseLive Cell Dye

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable