Skip to Content
Merck
All Photos(1)

Documents

460524

Sigma-Aldrich

Ethyl (S)-(−)-4-chloro-3-hydroxybutyrate

96%

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
ClCH2CH(OH)CH2CO2C2H5
CAS Number:
Molecular Weight:
166.60
Beilstein:
4657170
MDL number:
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

96%

optical activity

[α]23/D −14°, neat

optical purity

ee: 97% (GLC)

refractive index

n20/D 1.453 (lit.)

bp

93-95 °C/5 mmHg (lit.)

density

1.19 g/mL at 25 °C (lit.)

SMILES string

CCOC(=O)C[C@H](O)CCl

InChI

1S/C6H11ClO3/c1-2-10-6(9)3-5(8)4-7/h5,8H,2-4H2,1H3/t5-/m0/s1

InChI key

ZAJNMXDBJKCCAT-YFKPBYRVSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Ethyl (S)-4-chloro-3-hydroxybutanoate is a chiral intermediate generally used to prepare atorvastatin, a cholesterol-lowering drug.

Application

Ethyl (S)-(−)-4-chloro-3-hydroxybutyrate can be used as a starting material in the synthesis of 4-amino-3-hydroxybutyric acid, a compound of pharmacological importance.

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Cloning, expression and characterization of a highly active alcohol dehydrogenase for production of ethyl (S)-4-chloro-3-hydroxybutyrate
Zhu Y-H, et al.
Indian Journal of Microbiology, 59(2), 225-233 (2019)
Short synthesis of (R)-and (S)-4-amino-3-hydroxybutyric acid (GABOB).
Tiecco M, et al.
Synthesis, 2005(04), 579-582 (2005)
Efficient Asymmetric Synthesis of Ethyl (S)-4-Chloro-3-hydroxybutyrate Using Alcohol Dehydrogenase Sm ADH31 with High Tolerance of Substrate and Product in a Monophasic Aqueous System
Yang Z, et al.
Organic Process Research & Development, 24(6), 1068?1076-1068?1076 (2020)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service